Cholesterol-adjusted vitamin E serum levels are associated with cardiovascular events in patients with non-valvular atrial fibrillation
Abstract: Background: Non-valvular atrial fibrillation is associated with an increase in thromboembolism, i.e. stroke, and atherosclerotic events, i.e. myocardial infarction. Vitamin E possesses anti-coagulant as well as anti-atherosclerotic properties.Our aim was to assess whether vitamin E is associated with cardiovascular events in patients with non-valvular atrial fibrillation.Methods: Serum levels of cholesterol-adjusted vitamin E were measured in 1012 patients with non-valvular atrial fibrillation. Patients were followed for a mean time of 27.0months, and cardiovascular events, such as cardiovascular death and fatal and nonfatal stroke or myocardial infarction, were recorded.Results: During the follow-up period, cardiovascular events occurred in 109 (11%) patients (18 fatal and 14 nonfatal myocardial infarction; 13 fatal and 19 nonfatal ischemic strokes; 45 cardiovascular deaths). Lower vitamin E serum levels were found in patients who experienced cardiovascular events compared to those who did not (3.8±1.2 vs. 4.4±1.8μmol/mmol cholesterol; p
Source: International Journal of Cardiology - Category: Cardiology Authors: Roberto Cangemi, Pasquale Pignatelli, Roberto Carnevale, Gino Roberto Corazza, Daniele Pastori, Alessio Farcomeni, Stefania Basili, Giovanni Davì, Domenico Ferro, William R. Hiatt, Giuseppe Licata, Gregory Y.H. Lip, Lorenzo Loffredo, Pier Mannuccio Mannu Tags: Original Articles Source Type: research
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