Pilot Study to Evaluate the Effect of Nicotinamide Riboside on Immune Activation in Psoriasis

Conditions:   Psoriasis;   Atherosclerotic Cardiovascular Disease;   Obesity;   Dyslipidemia;   Cardiometabolic Diseases Interventions:   Dietary Supplement: Niagen;   Other: Placebo Sponsor:   National Heart, Lung, and Blood Institute (NHLBI) Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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This study examined weight reduction as well as smoking as potential modifiable risk factors for PsA.The British Journal of Dermatology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Dermatology Journal Article Source Type: news
Abstract Psoriatic arthritis is an inflammatory arthropathy frequently associated with psoriasis and several other comorbidities. The goal of this review is to summarize the available evidence on the epidemiology, clinical implications, pathological mechanisms proposed, and screening and management recommendations for the comorbidities related with PsA. Reported comorbidities include cardiovascular disease, metabolic syndrome, obesity, diabetes mellitus, dyslipidemia, inflammatory bowel disease, fatty liver disease, uveitis, kidney disease, infections, osteoporosis, depression, central sensitization syndrome, and ...
Source: Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Clin Immunol Source Type: research
PMID: 32107778 [PubMed - in process]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research
Psoriasis is a chronic, systemic immune-mediated disease characterized by development of erythematous, indurated, scaly, pruritic plaques on the skin. Psoriasis is frequently associated to comorbidities, including psoriatic arthritis, cardiovascular diseases, diabetes mellitus, obesity, non-alcoholic fatty liver disease, and inflammatory bowel diseases. In this review, we discuss the pathophysiological relationship between psoriasis and cardio-metabolic comorbidities and the importance of therapeutic strategies to reduce systemic inflammation in patients with moderate-to-severe psoriasis. Pathogenesis of psoriasis and its ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Conditions:   Psoriasis;   Atherosclerotic Cardiovascular Disease;   Obesity;   Dyslipidemia;   Cardiometabolic Diseases Interventions:   Dietary Supplement: Niagen;   Other: Placebo Sponsor:   National Heart, Lung, and Blood Institute (NHLBI) Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease that affects 1% to 4% of the Western population and is associated with major impact on quality of life. Its pathogenesis, combining hair follicle dysregulation and both skin and systemic inflammation, involves a genetic background interacting with environmental factors (eg, bacterial skin dysbiosis, overweight, smoking).1 TNF- α, which is enhanced in HS, is upregulated in other immune-mediated inflammatory diseases (IMIDs) such as severe psoriasis vulgaris (PV), inflammatory bowel disease (IBD), and spondyloarthritis.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Letters to the Editor Source Type: research
We report a case occurring during acitretin treatment for psoriasis. PATIENTS AND METHODS: A 27-year-old male patient with no history of diabetes, obesity, alcohol consumption or medication consulted for extensive pustular psoriasis. The lipid balance and liver tests were normal. The patient was treated with acitretin at a dose of 25mg/d. Four days after the start of treatment, the patient was admitted to the surgical emergency room for piercing epigastric pain with vomiting of bile, without transit problems. Serum lipase was 20 times the normal value (1278 IU/L). CRP was raised at 155mg/L and triglycerides were norma...
Source: Annales de Dermatologie et de Cenereologie - Category: Dermatology Authors: Tags: Ann Dermatol Venereol Source Type: research
A Western diet (WD) —characterized by its high fat and simple sugar content—is thought to predispose individuals to inflammatory skin diseases such as psoriasis, through the development of obesity. This scenario, however, is being challenged by emerging data suggesting that dietary components, rather than obesity i tself, may exacerbate psoriasis. We herein show that short-term feeding with a diet analogous to the WD in mice leads to Th1/Th17-biased skin inflammation before significant body weight gain.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Original Article Source Type: research
Conclusions: We have demonstrated an abnormal sphingolipid profile in psoriatic patients in different weight groups. Selected CER might be the biomarkers of psoriasis severity and inflammation, may reflect lipid disturbances and contribute to the development of metabolic syndrome. PMID: 31998000 [PubMed]
Source: Advances in Dermatology and Allergology - Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research
WEDNESDAY, Jan. 29, 2020 -- Obesity does not necessarily induce or contribute to familial psoriasis, according to a study published online Jan. 17 in the Journal of Dermatology. Bolortuya Bayaraa, M.D., from Fukuoka University in Japan, and...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
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