Functional characterization and circulating expression profile of dysregulated microRNAs in BAV-associated aortopathy

In conclusion, our study demonstrated that miR-424-3p and miR-3688-3p directly targeted SMAD7 and YAP1 in HASMCs, pivotal genes of the TGF-β and Hippo-signaling pathways. Circulating miR-424-3p was also found to be significantly de creased in BAV patients when compared to TAV patients, especially in patients with aortic stenosis. Further large studies of well-characterized BAV patient cohorts are needed to define the clinical significance of the miR-424-3p.

http://link.springer.com/10.1007/s00380-019-01509-8

Source: Heart and Vessels - February 17, 2020 Category: Cardiology Source Type: research