Gene polymorphisms and motor levodopa ‐induced complications in Parkinson's disease

ConclusionsOur results confirmed the association of rs6265 BDNF (Val66Met) with the risk of PD and suggest a synergic effect of rs6265 BDNF (Val66Met), rs397595 DAT (SLC6A3), and rs4680 COMT (Val158Met) polymorphisms on the occurrence of MLIC.
Source: Brain and Behavior - Category: Neurology Authors: Tags: ORIGINAL RESEARCH Source Type: research

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Condition:   Parkinson's Disease Interventions:   Drug: TAK-071;   Drug: Placebo Sponsor:   Takeda Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 4 April 2020Source: Stem Cell ResearchAuthor(s): Simone B. Larsen, Zoé Hanss, Gérald Cruciani, François Massart, Peter A. Barbuti, George Mellick, Rejko Krüger
Source: Stem Cell Research - Category: Stem Cells Source Type: research
EU-funded researchers have developed innovative genetic reprogramming techniques to replace and repair brain cells, opening up novel therapeutic pathways to combat debilitating disorders such as Parkinson's and Huntington's disease.
Source: EUROPA - Research Information Centre - Category: Research Source Type: news
Authors: Kang JH, Kim MH, Lee HJ, Huh JW, Lee HS, Lee DS Abstract High concentrations of glutamate induce neurotoxicity by eliciting reactive oxygen species (ROS) generation and intracellular Ca2+ influx. The disruption of Ca2+ homeostasis in the endoplasmic reticulum (ER) evokes ER stress, ultimately resulting in neuronal dysfunction. Additionally, glutamate participates in the development of neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases. Peroxiredoxins (Prxs) are members of a family of antioxidant enzymes that protect cells from neurotoxic factor-induced apoptosis by scavenging hydrogen...
Source: Free Radical Research - Category: Research Tags: Free Radic Res Source Type: research
OBJECTIVE: To investigate the effect of task prioritization on dual-task control in Parkinson disease (PD) associated with different postural impairments. DESIGN: Cross-sectional study. Participants were instructed to keep two interlocking rings ap...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
OBJECTIVE: Determining if traumatic brain injury (TBI) and posttraumatic stress disorder (PTSD) are risk factors for Parkinson's disease (PD). This constitutes a research priority for the Veterans Administration (VA) with implications for screening policy ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Burns, Electricity, Explosions, Fire, Scalds Source Type: news
Publication date: Available online 4 April 2020Source: Journal of EthnopharmacologyAuthor(s): Ying-Nan Jiang, Yong-Zhi Guo, Dan-Hua Lu, Ming-Hai Pan, Hai-Zhi Liu, Gen-Long Jiao, Wei Bi, Hiroshi Kurihara, Yi-Fang Li, Wen-Jun Duan, Rong-Rong He, Xin-Sheng Yao
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
AbstractMalnutrition risk (MR) prevalence in Parkinson ’s Disease (PD) is 3–60%. Mini-Nutritional Assessment (MNA) and MNA-SF are the widely Query used measurements for MR. The aim of this study was to identify if MNA-SF is sufficient to detect MR instead of total MNA in PD. Participants were compared in terms of anthropometric measurements, MNA (to tal, screening and evaluation), non-motor questionnaire, beck depression inventory, beck anxiety inventory. They were additionally compared according to evaluation part of MNA. All PD patients were divided into two groups as “with MR” and “without ...
Source: Acta Neurologica Belgica - Category: Neurology Source Type: research
Abstract Discriminatory drug delivery into target cells is essential to effectively elicit the drug activity and to avoid off-target side effects; however, transporting drugs across the cell membrane is difficult due to factors such as molecular size, hydrophilicity, intercellular adhesiveness, and efflux transporters, particularly, in the brain capillary endothelial cells. Drug delivery into the brain is blocked by the blood-brain barrier (BBB). Thus, developing drugs for the central nervous system (CNS) diseases remains a challenge. The approach based on receptor-mediated transcytosis (RMT) can overcome this imp...
Source: Chemical and Pharmaceutical Bulletin - Category: Drugs & Pharmacology Authors: Tags: Chem Pharm Bull (Tokyo) Source Type: research
INTRODUCTION: In the elderly, functional balance, fear of falling, and independence in daily living activities are interrelated; however, this relationship may change under the influence of drug phase and the severity of disease in individuals with idiopat...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
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