Cytochrome P450-Based Drug-Drug Interactions of Vonoprazan In Vitro and In Vivo

ConclusionThe in vitro and in vivo results indicated that vonoprazan can inhibit CYP3A4, CYP2C9, CYP2D6, and CYP2B6, suggesting that the coadministration of vonoprazan with cytochrome P450 substrates should be performed cautiously in clinical settings.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research