An oxide transport chain essential for balanced insulin action

Patients with overnutrition, obesity, the atherometabolic syndrome, and type 2 diabetes typically develop fatty liver, atherogenic dyslipoproteinemia, hyperglycemia, and hypertension. These features share an unexplained origin – namely, imbalanced insulin action, also called pathway-selective insulin resistance and responsiveness. To control glycemia, these patients require hyperinsulinemia that then overdrives ERK and hepatic de-novo lipogenesis. We previously reported that NADPH oxidase-4 regulates balanced insulin ac tion, but the model appeared incomplete.

Source: Atherosclerosis - February 12, 2020 Category: Cardiology Authors: Xiangdong Wu, Keyang Chen, Kevin Jon Williams Source Type: research