Manual acupuncture for patients with major depressive disorder and comorbid insomnia: Evidence from Polysomnography and serum biomarkers

Conclusion(1) MA may be a potential alternative therapy for improving MDD and comorbid insomnia (particularly in extending total sleep time and shortening wake-up duration and sleep latency) via upregulating the expression of NPY and downregulating the expression of SP; more importantly, this efficacy of acupuncture can not be replaced by sham-acupuncture acting on the same acupoints with the same treatment frequency. (2) There is insufficient evidence to prove that MA can effectively reduce the number of arousals.
Source: World Journal of Acupuncture Moxibustion - Category: Complementary Medicine Source Type: research

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n D Abstract In the current global home confinement situation due to the COVID-19 outbreak, most individuals are exposed to an unprecedented stressful situation of unknown duration. This may not only increase daytime stress, anxiety and depression levels but also disrupt sleep. Importantly, because of the fundamental role that sleep plays in emotion regulation, sleep disturbance can have direct consequences upon next day emotional functioning. In this paper we summarize what is known about the stress-sleep link and confinement as well as effective insomnia treatment. We discuss those effects of the current home co...
Source: Journal of Sleep Research - Category: Sleep Medicine Authors: Tags: J Sleep Res Source Type: research
Insomnia is a common sleep disorder for adults with depression, with major impact on their quality of life. Previous trials suggest that listening to music may be helpful in the treatment of sleep disturbances...
Source: Trials - Category: General Medicine Authors: Tags: Study protocol Source Type: research
Conclusions The weak associations of sleep quality with sleep disorders and objectively measured sleep disturbances are consistent with concepts of “sleep health” as a multidimensional construct. Sleep quality is a patient-centered outcome that provides unique information over objective measurements of sleep disturbances.
Source: Psychosomatic Medicine - Category: Psychiatry & Psychology Tags: ORIGINAL ARTICLES Source Type: research
AbstractOrexins comprise two neuropeptides produced by orexin neurons in the lateral hypothalamus and are released by extensive projections of these neurons throughout the central nervous system. Orexins bind and activate their associated G protein-coupled orexin type 1 receptors (OX1Rs) and OX2Rs and act on numerous physiological processes, such as sleep-wake regulation, feeding, reward, emotion, and motivation. Research on the development of orexin receptor antagonists has dramatically increased with the approval of suvorexant for the treatment of primary insomnia. In the present review, we discuss recent findings on the...
Source: Neuroscience Bulletin - Category: Neuroscience Source Type: research
Abstract Objective/Background: Insomnia and depression are disorders that affect many perinatal women and that often are interrelated. The present study aimed to examine concurrent and prospective associations between mid-pregnancy insomnia and depression during mid-pregnancy and 8 weeks postpartum. Furthermore, differences in depression and in the sleep-related characteristics insomnia, chronotype, and sleep efficiency were explored between the two time points (mid-pregnancy versus 8 weeks postpartum), and between primiparous and multiparous participants.Participants/Methods: The study was part of the N...
Source: Behavioral Sleep Medicine - Category: Sleep Medicine Authors: Tags: Behav Sleep Med Source Type: research
__ Pear gets FDA clearance for insomnia therapeutic (MedCity News): “Pear Therapeutics received marketing authorization for its third product — a digital therapeutic intended to treat chronic insomnia. Called Somryst, the app is available by prescription only. It consists of a nine-week program that includes cognitive behavioral therapy and restricting sleep to a limited window of time … The company’s submission included data from two randomized controlled trials, including a study of 1,100 adults reporting chronic insomnia that used Somryst for nine weeks. They saw a significant reduction in insom...
Source: SharpBrains - Category: Neuroscience Authors: Tags: Cognitive Neuroscience Health & Wellness Technology chronic insomnia cognitive-behavioral-therapy depression digital therapeutic FDA Pear Therapeutics precertification Somryst Source Type: blogs
A causal relationship between sleep disturbances and suicidal behavior has been previously reported. Insomnia and nightmares are considered as hallmarks of posttraumatic stress disorder (PTSD). In addition, patients with PTSD have an increased risk for sui...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
AbstractRefugees affected by multiple traumatic stressors are at high risk for developing trauma ‐related mental disorders, including posttraumatic stress disorder (PTSD), depression, and insomnia, which is sometimes overlooked. The present study examined the effectiveness of narrative exposure therapy (NET) on trauma‐related symptoms in a sample of North Korean refugee youth. We focused on sleep patterns in addition to changes in symptom severity for PTSD, depression, and internalizing and externalizing symptoms. North Korean refugee youth (N = 20) with PTSD were assigned to either an NET ‐based treatment group or a...
Source: Journal of Traumatic Stress - Category: Psychiatry & Psychology Authors: Tags: BRIEF REPORT Source Type: research
AbstractPrevious research has demonstrated that sleep disturbances show little improvement with evidence ‐based psychotherapy for posttraumatic stress disorder (PTSD); however, sleep improvements are associated with PTSD treatment outcomes. The goal of the current study was to evaluate changes in self‐reported insomnia symptoms and the association between insomnia symptoms and treatment outcome dur ing a 3‐week intensive treatment program (ITP) for veterans with PTSD that integrated cognitive processing therapy (CPT), mindfulness, yoga, and other ancillary services. As part of standard clinical procedures, veterans (...
Source: Journal of Traumatic Stress - Category: Psychiatry & Psychology Authors: Tags: Research Article Source Type: research
DiscussionThis is the first randomised controlled trial to combine CBT and BLT for the treatment of sleep disturbance in women with breast cancer. This novel design addresses the multiple causal factors for sleep complaints in this population. Results from this trial will advance knowledge in this field and may have important clinical implications for how best to treat sleep disturbance and insomnia in this population. If effective, the largely email-based format of the intervention would allow for relatively easy translation.Trial RegistrationAustralian New Zealand Clinical Trials Registry (ANZCTR),ACTRN12618001255279. Re...
Source: Trials - Category: Research Source Type: clinical trials
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