Naringin inhibits autophagy mediated by PI3K-Akt-mTOR pathway to ameliorate endothelial cell dysfunction induced by high glucose/high fat stress.

In conclusion, Nar improves the function of HUVECs under HG/HF stress through activating the PI3K-Akt-mTOR pathway to inhibit autophagy. The findings offer an insight into HG/HF stress-induced autophagy and indicate that Nar might have potential to prevent and treat the diabetic angiopathy.
PMID: 32045600 [PubMed - as supplied by publisher]

Source: European Journal of Pharmacology - February 7, 2020 Category: Drugs & Pharmacology Authors: Wang K, Peng S, Xiong S, Niu A, Xia M, Xiong X, Zeng G, Huang Q Tags: Eur J Pharmacol Source Type: research