Mitochondrial Adaptations in the Growing Heart.

Mitochondrial Adaptations in the Growing Heart.
Trends Endocrinol Metab. 2020 Feb 05;:
Authors: Sánchez-Díaz M, Nicolás-Ávila JÁ, Cordero MD, Hidalgo A
Abstract
The heart pumps blood throughout the whole life of an organism, without rest periods during which to replenish energy or detoxify. Hence, cardiomyocytes, the working units of the heart, have mechanisms to ensure constitutive production of energy and detoxification to preserve fitness and function for decades. Even more challenging, the heart must adapt to the varying conditions of the organism from fetal life to adulthood, old age, and pathological stress. Mitochondria are at the nexus of these processes by producing not only energy but also metabolites and oxidative byproducts that can activate alarm signals and be toxic to the cell. We review basic concepts about cardiac mitochondria with a focus on their remarkable adaptations, including elimination, throughout the mammalian lifetime.
PMID: 32035734 [PubMed - as supplied by publisher]

Source: Trends in Endocrinology and Metabolism: TEM - February 4, 2020 Category: Endocrinology Authors: Sánchez-Díaz M, Nicolás-Ávila JÁ, Cordero MD, Hidalgo A Tags: Trends Endocrinol Metab Source Type: research