Cerebral Hemodynamic Changes After Revascularization in Patients With Hemorrhagic Moyamoya Disease

Conclusion: In patients with hemorrhagic MMD, the CBV appeared to decrease and be relatively stable in the chronic phase after revascularization, with varying degrees of MTT and TTP shortening. However, there was no significant change in CBF.
Source: Frontiers in Neurology - Category: Neurology Source Type: research

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Abstract RATIONALE: Large decreases in PaCO2 that occur when initiating extracorporeal membrane oxygenation (ECMO) in patients with respiratory failure may cause cerebral vasoconstriction and compromise brain tissue perfusion. OBJECTIVES: To determine if the magnitude of PaCO2 correction upon ECMO initiation is associated with an increased incidence of neurological complications in patients with respiratory failure. METHODS: We conducted a multicenter international retrospective cohort study using the Extracorporeal Life Support Organization (ELSO) Registry, including adults with respiratory failure on a...
Source: American Journal of Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Am J Respir Crit Care Med Source Type: research
AbstractThe role of hyperosmolar therapy (HT) in large hemispheric ischemic or hemorrhagic strokes remains a controversial issue. Past and current stroke guidelines state that it represents a reasonable therapeutic measure for patients with either neurological deterioration or intracranial pressure (ICP) elevations documented by ICP monitoring. However, the lack of evidence for a clear effect of this therapy on radiological tissue shifts and clinical outcomes produces uncertainty with respect to the appropriateness of its implementation and duration in the context of radiological mass effect without clinical correlates of ...
Source: Neurocritical Care - Category: Neurology Source Type: research
AbstractDirect stenting (DS) without pre-dilatation of the culprit lesion might improve myocardial perfusion and prognosis in patients undergoing percutaneous coronary intervention for ST-elevation myocardial infarction (STEMI); however, some studies report conflicting results. We investigated whether DS provides incremental myocardial benefits over conventional stenting (CS) in STEMI patients based on cardiac magnetic resonance imaging (CMR) measures. Reperfused patients who underwent CMR examinations within 1  week of STEMI onset were selected from a multicenter CMR registry of STEMI (NCT: 03768453). Patients were s...
Source: The International Journal of Cardiovascular Imaging - Category: Radiology Source Type: research
AbstractInconsistency in outcome parameters for delayed cerebral ischemia (DCI) makes it difficult to compare results between mouse studies, in the same way inconsistency in outcome parameters in human studies has for long obstructed adequate comparison. The absence of an established definition may in part be responsible for the failed translational results. The present article proposes a standardized definition for DCI in experimental mouse models, which can be used as outcome measure in future animal studies. We used a consensus-building approach to propose a definition for “experimental secondary ischemia” (...
Source: Translational Stroke Research - Category: Neurology Source Type: research
Purpose of review This review summarizes the physiological basis of autoregulation-oriented therapy in critically ill patients, with a particular emphasis on individual targets based on parameters that describe autoregulation of cerebral blood flow. Recent findings The concepts of optimal cerebral perfusion (CPPopt) and arterial pressures (ABPopt), which both take advantage of continuous measures of cerebral autoregulation, recently have been introduced into clinical practice. It is hypothesized that if both pressures are used as individual targets and followed, the incidence and severity of dysautoregulation will dim...
Source: Current Opinion in Critical Care - Category: Nursing Tags: ACUTE NEUROLOGICAL PROBLEMS: Edited by Peter Le Roux Source Type: research
Authors: White H, Venkatesh B, Jones M, Kruger PS, Walsham J, Fuentes H Abstract Objective: Although extensively studied in children, the safety and tolerability of ketone supplementation in adults is unclear, particularly in the acute brain injury population. The purpose of this study was to examine the feasibility and safety of inducing ketosis using an enteric ketogenic formulation and determine its impact on intracranial and cerebral perfusion pressures and metabolic parameters.Methods: Prospective interventional Phase II trial of ventilated critically ill patients with acute brain injury administered a ketogen...
Source: Neurological Research - Category: Neurology Tags: Neurol Res Source Type: research
Objective: To explore the value of whole-brain perfusion parameters combined with multiphase computed tomography angiography (MP-CTA) in predicting the hemorrhagic transformation (HT) of ischemic stroke. Methods: A total of 64 patients with ischemic stroke who underwent noncontrast computed tomography, computed tomography perfusion imaging, and computed tomography angiography before treatment from August 2017 to June 2019 were included retrospectively. The perfusion parameters cerebral blood volume (CBV), cerebral blood flow (CBF), time to peak (TTP), mean transit time (MTT), time to maximum (Tmax), and permeability surfac...
Source: Journal of Stroke and Cerebrovascular Diseases - Category: Neurology Authors: Source Type: research
The combination of radiomics and a machine-learning algorithm can determine...Read more on AuntMinnie.comRelated Reading: AI may help improve management of stroke patients AI finds infarction in stroke patients on unenhanced CT CT plus CT perfusion predicts stroke surgery outcomes CTA lowers costs, improves outcomes for minor stroke Can AI find brain hemorrhage as well as radiologists?
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
ConclusionOur everyday clinical practice experience suggests 9.8  % of consecutive AIS patients present in the 4.5–9 h window and 2.2 % adhere to EXTEND neuroimaging eligibility criteria for IVT. Only 1.3% of AIS is eligible for IVT according to EXTEND neuroimaging and clinical eligibility criteria.
Source: Neuroradiology - Category: Radiology Source Type: research
Canadian researchers found that their artificial intelligence (AI) algorithm...Read more on AuntMinnie.comRelated Reading: CT plus CT perfusion predicts stroke surgery outcomes CTA lowers costs, improves outcomes for minor stroke Can AI find brain hemorrhage as well as radiologists? Mobile CT unit boosts efficiency of stroke triage SIR: Stroke treatment training program improves outcomes
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
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