Association of Tramadol Use With Risk of Hip Fracture

This study aimed to examine the association of tramadol with risk of hip fractur e. Among individuals age 50 years or older without a history of hip fracture, cancer, or opioid use disorder in The Health Improvement Network (THIN) database in the United Kingdom general practice (2000–2017), five sequential propensity score–matched cohort studies were assembled, ie, partici pants who initiated tramadol or those who initiated one of the following medications: codeine (n = 146,956) (another commonly used weak opioid), naproxen (n = 115,109) or ibuprofen (n = 107,438) (commonly used nonselective nonsteroidal anti ‐inflammatory drugs [NSAIDs]), celecoxib (n = 43,130), or etoricoxib (n = 27,689) (cyclooxygenase ‐2 inhibitors). The outcome was incident hip fracture over 1 year. After propensity‐score matching, the included participants had a mean age of 65.7 years and 56.9% were women. During the 1‐year follow‐up, 518 hip fracture (3.7/1000 person‐years) occurred in the tramadol cohort and 401 ( 2.9/1000 person‐years) occurred in the codeine cohort. Compared with codeine, hazard ratio (HR) of hip fracture for tramadol was 1.28 (95% confidence interval [CI] 1.13 to 1.46). Risk of hip fracture was also higher in the tramadol cohort than in the naproxen (2.9/1000 person‐years for tramadol, 1.7/1000 person‐years for naproxen; HR = 1.69, 95% CI 1.41 to 2.03), ibuprofen (3.4/1000 person‐years for tramadol, 2.0/1000 person‐years for ibuprofen...
Source: Journal of Bone and Mineral Research - Category: Orthopaedics Authors: Tags: Original Article Source Type: research

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Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
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Source: Protein Science - Category: Biochemistry Authors: Tags: Review Source Type: research
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Source: Journal of Palliative Medicine - Category: Palliative Care Authors: Source Type: research
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Source: Protein Science - Category: Biochemistry Authors: Tags: Review Source Type: research
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Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Anxiety and Panic General Medications Not Crazy Podcast Source Type: blogs
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Source: Pain - Category: Anesthesiology Tags: Systematic Review and Meta-Analysis Source Type: research
Source: Journal of Pain Research - Category: Anesthesiology Tags: Journal of Pain Research Source Type: research
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Source: Molecular Brain - Category: Neuroscience Authors: Tags: Research Source Type: research
Conditions:   Chronic Pain Syndrome;   Psychology, Social Intervention:   Behavioral: Pain management program Sponsor:   Taipei Veterans General Hospital, Taiwan Not yet recruiting
Source: - Category: Research Source Type: clinical trials
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Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
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