Inhibition of NADPH Oxidase 5 (NOX5) Suppresses High Glucose-Induced Oxidative Stress, Inflammation and Extracellular Matrix Accumulation in Human Glomerular Mesangial Cells.

CONCLUSIONS Taken together, these findings demonstrated that inhibition of NOX5 attenuated HG-induced HMCs oxidative stress, inflammation, and ECM accumulation, suggesting that NOX5 may serve as a potential therapeutic target for diabetic nephropathy (DN) treatment. PMID: 32012145 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/32012145?dopt=Abstract

Source: Medical Science Monitor - February 6, 2020 Category: Research Tags: Med Sci Monit Source Type: research