Haematological protective effect of raw extract and nano- Eclipta alba –treated rats in experimentally induced hepatocarcinogenesis

The objective of the present study was to evaluate the effect ofEclipta alba (L.) andE. alba nanoparticles on haematological and hepatoprotective parameters in diethyl nitrosamine (DEN) –induced toxicity and hepatocarcinogenesis model in rats. Eighty-one Wistar albino rats were divided into four groups. Group I control (n = 19), group II DEN .01% in water (n = 19), group III (DEN+ rawE. alba 50  mg/kg BW/day) and group IV (DEN+ nano-E. alba 50  mg/kg BW/day). DEN group (II) showed a significant (P <  0.05) decrease in the haemoglobin (Hb), PCV, total erythrocyte and platelet value whereas total leucocyte count (TLC) and absolute neutrophil count showed a significant (P <  0.05) increase when compared with the sham control group. Thus,E. alba nanoparticle treatment was able to offer better protection as compared with the rawE. alba against DEN toxicity. Anaemic changes and thrombocytopenia were less inE. alba treatments. Nano-E. alba could be capable to alleviate the DEN toxicity.
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research