Clinical Rating Scales and Quantitative Assessments of Movement Disorders

This article reviews scales that have been developed for, validated in, and/or frequently used across multiple movement disorders with a focus on assessment of motor and nonmotor symptoms of Parkinson disease. Rating scales used in other disease states include those for essential tremor, dystonia (generalized dystonia, cervical dystonia, and blepharospasm), Tourette syndrome, Huntington disease, tardive dyskinesia, Wilson disease, ataxia, and functional movement disorders. Key features of each scale as well as cited criticisms and limitations of each scale are also discussed. Lastly, the article briefly discusses the emerging role of digital assessment tools (both wearable devices and digital interface applications).
Source: Neurologic Clinics - Category: Neurology Authors: Source Type: research

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Authors: Kang JH, Kim MH, Lee HJ, Huh JW, Lee HS, Lee DS Abstract High concentrations of glutamate induce neurotoxicity by eliciting reactive oxygen species (ROS) generation and intracellular Ca2+ influx. The disruption of Ca2+ homeostasis in the endoplasmic reticulum (ER) evokes ER stress, ultimately resulting in neuronal dysfunction. Additionally, glutamate participates in the development of neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases. Peroxiredoxins (Prxs) are members of a family of antioxidant enzymes that protect cells from neurotoxic factor-induced apoptosis by scavenging hydrogen...
Source: Free Radical Research - Category: Research Tags: Free Radic Res Source Type: research
OBJECTIVE: To investigate the effect of task prioritization on dual-task control in Parkinson disease (PD) associated with different postural impairments. DESIGN: Cross-sectional study. Participants were instructed to keep two interlocking rings ap...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
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Source: SafetyLit - Category: International Medicine & Public Health Tags: Burns, Electricity, Explosions, Fire, Scalds Source Type: news
Publication date: Available online 4 April 2020Source: Journal of EthnopharmacologyAuthor(s): Ying-Nan Jiang, Yong-Zhi Guo, Dan-Hua Lu, Ming-Hai Pan, Hai-Zhi Liu, Gen-Long Jiao, Wei Bi, Hiroshi Kurihara, Yi-Fang Li, Wen-Jun Duan, Rong-Rong He, Xin-Sheng Yao
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
AbstractMalnutrition risk (MR) prevalence in Parkinson ’s Disease (PD) is 3–60%. Mini-Nutritional Assessment (MNA) and MNA-SF are the widely Query used measurements for MR. The aim of this study was to identify if MNA-SF is sufficient to detect MR instead of total MNA in PD. Participants were compared in terms of anthropometric measurements, MNA (to tal, screening and evaluation), non-motor questionnaire, beck depression inventory, beck anxiety inventory. They were additionally compared according to evaluation part of MNA. All PD patients were divided into two groups as “with MR” and “without ...
Source: Acta Neurologica Belgica - Category: Neurology Source Type: research
Abstract Discriminatory drug delivery into target cells is essential to effectively elicit the drug activity and to avoid off-target side effects; however, transporting drugs across the cell membrane is difficult due to factors such as molecular size, hydrophilicity, intercellular adhesiveness, and efflux transporters, particularly, in the brain capillary endothelial cells. Drug delivery into the brain is blocked by the blood-brain barrier (BBB). Thus, developing drugs for the central nervous system (CNS) diseases remains a challenge. The approach based on receptor-mediated transcytosis (RMT) can overcome this imp...
Source: Chemical and Pharmaceutical Bulletin - Category: Drugs & Pharmacology Authors: Tags: Chem Pharm Bull (Tokyo) Source Type: research
INTRODUCTION: In the elderly, functional balance, fear of falling, and independence in daily living activities are interrelated; however, this relationship may change under the influence of drug phase and the severity of disease in individuals with idiopat...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
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Source: International Journal of Speech-Language Pathology - Category: Speech-Language Pathology Authors: Source Type: research
We report the case of a 20-year-old man with atopic dermatitis treated with dupilumab for half a year, who presented with sudden onset of dizziness, nausea, and slight cerebellar ataxia. Brain magnetic resonance imaging revealed acute infarction in the bicerebellar hemispheres.
Source: Journal of Stroke and Cerebrovascular Diseases - Category: Neurology Authors: Source Type: research
AbstractWilson disease (WD) is a genetic disorder of copper metabolism caused by variants in the copper transporting P-type ATPase geneATP7B. Estimates for WD population prevalence vary with 1 in 30,000 generally quoted. However, some genetic studies have reported much higher prevalence rates. The aim of this study was to estimate the population prevalence of WD and the pathogenicity/penetrance of WD variants by determining the frequency ofATP7B variants in a genomic sequence database. A catalogue of WD-associatedATP7B variants was constructed, and then, frequency information for these was extracted from the gnomAD data se...
Source: Human Genetics - Category: Genetics & Stem Cells Source Type: research
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