Radiosurgery to the spinal dorsal root ganglion induces fibrosis and inhibits satellite glial cell activation while preserving axonal neurotransmission.

CONCLUSIONS: SRS did not alter sensory or motor function but reduced the activation of satellite glial cells, a pathway for DRG-mediated pain perpetuation. Radiosurgery provoked changes equivalent to the effects of focal radiation on the trigeminal ganglion after SRS for trigeminal neuralgia, suggesting that radiosurgery could be successful in relieving radiculopathic pain. PMID: 32005015 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32005015?dopt=Abstract

Source: Journal of Neurosurgery.Spine - January 30, 2020 Category: Neurosurgery Authors: Goldschmidt E, Fellows-Mayle W, Wolfe R, Niranjan A, Flickinger JC, Lunsford LD, Gerszten PC Tags: J Neurosurg Spine Source Type: research