Hemophagocytic syndrome following alemtuzumab treatment for multiple sclerosis: A case report.

Conclusion: HS is a severe condition marked by an excessive activation of the immune system that leads to a rapid and progressive multi-organ failure, so it is important to consider it in the differential diagnosis of a fever syndrome following the administration of alemtuzumab.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research

Related Links:

This article also includes supplemental videos showcasing OMT techniques for asthma management, which were developed by the authors based on recommendations indicated in the literature. PMID: 32961555 [PubMed - as supplied by publisher]
Source: Journal of the American Osteopathic Association - Category: Complementary Medicine Tags: J Am Osteopath Assoc Source Type: research
The focus of this review is the role of complement-mediated phagocytosis in retinal and neurological diseases affecting the visual system. Complement activation products opsonize synaptic material on neurons for phagocytic removal, which is a normal physiological process during development, but a pathological process in several neurodegenerative diseases and conditions. We discuss the role of complement in the refinement and elimination of synapses in the retina and lateral geniculate nucleus, both during development and in disease states. How complement and aberrant phagocytosis promotes injury to the visual system is dis...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Conclusion: HS is a severe condition marked by an excessive activation of the immune system that leads to a rapid and progressive multi-organ failure, so it is important to consider it in the differential diagnosis of a fever syndrome following the administration of alemtuzumab.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
We present a 45-year-old Caucasian woman with a history of multiple sclerosis who presented to the hospital with 4 weeks of epigastric pain, nausea, intermittent bilious emesis, and new jaundice. She reported daily intake of 2 –3 glasses of wine over the past 15 years. She denied recent travel or use of acetaminophen, herbal supplements, or any new medications. Laboratory results showed hemoglobin of 11.6 g/dL, white blood cell count of 16.0 × 103/μL, and a platelet count of 272 × 103/μL.
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Clinical Challenges and Images in GI Source Type: research
We present a 45-year-old Caucasian woman with a history of multiple sclerosis who presented to the hospital with 4 weeks of epigastric pain, nausea, intermittent bilious emesis, and new jaundice. She reported daily intake of 2 –3 glasses of wine over the past 15 years. She denied recent travel or use of acetaminophen, herbal supplements, or any new medications. Laboratory results showed hemoglobin of 11.6 g/dL, white blood cell count of 16.0 × 103/μL, and a platelet count of 272 × 103/μL.
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Clinical Challenges and Images in GI Source Type: research
This article brings the choroid plexus into the context of health and disease. It is remarkable that the choroid plexus, composed by the monolayer of epithelial cells that lie in a highly vascularized stroma, floating within the brain ventricles, gets so little attention in major physiology and medicine text books and in the scientific literature in general. Consider that it is responsible for producing most of the about 150mL of cerebrospinal fluid that fills the brain ventricles and the subarachnoid space and surrounds the spinal cord in the adult human brain, which is renewed approximately 2-3 times daily. As such, its ...
Source: Neurobiology of Disease - Category: Neurology Authors: Tags: Neurobiol Dis Source Type: research
Conclusions The hepatitis B vaccination program targeting newborns and infants does NOT make sense. The vaccination itself has not proven to be effective in preventing hepatitis B. There is very little risk of children becoming infected with hepatitis B. Hepatitis B is a disease that is not highly infectious and tends to affect adults in high risk groups. The course of the disease is usually self-limiting with lifelong immunity acquired. In contrast, many serious health consequences have resulted from the hepatitis B vaccination, including permanent disability and death.   References http://www.nvic.org/nvic-archives...
Source: vactruth.com - Category: Allergy & Immunology Authors: Tags: Logical Michelle Goldstein Top Stories adverse reactions Hepatitis B vaccine truth about vaccines Source Type: blogs
There’s something you should know about chronic kidney disease. Most doctors will tell you there is no alternative treatments for kidney problems besides costly dialysis or a transplant to deal with impaired renal function. What Is Kidney Failure? Kidney dialysis is a treatment that uses a special machine to filter harmful wastes, salt and excess from your blood. But there is another option. It’s called stem cell biotherapy, and it offers new hope to those with this life-threatening disease. You may think your kidneys are just fine and you have nothing to worry about. But consider this… What Causes Kidn...
Source: Al Sears, MD Natural Remedies - Category: Complementary Medicine Authors: Tags: Health Source Type: news
CONCLUSIONS: This case of fatal autoimmune hemolytic anemia associated with alemtuzumab treatment adds further evidence to the potential risk of antibody mediated side effects and argues for close hematological monitoring of patients.Disclosure: Dr. Rieckmann has received personal compensation for activities with Bayer, Biogen Idec, Boehringer Ingelheim, Novartis, Merck-Serono, Teva, and Genzyme. Dr. Lenz has nothing to disclose. Dr. Hoffmann has nothing to disclose. Dr. Poske has nothing to disclose. Dr. Behr has nothing to disclose. Dr. Kallmann has received honoraria for serving on advisory boards and as speaker from Me...
Source: Neurology - Category: Neurology Authors: Tags: MS and CNS Inflammatory Disease: Treatment, Safety, and Tolerance Source Type: research
Publication date: November–December 2015 Source:Neurologia i Neurochirurgia Polska, Volume 49, Issue 6 Author(s): Dorota Kozielewicz, Małgorzata Pawłowska In the treatment of multiple sclerosis (MS), interferon beta (IFNβ) applies. It rarely can lead to acute liver failure (ALF). A 42-year-old female with MS was admitted to the Department because of jaundice, general weakness, drowsiness and nausea. Four weeks earlier, she had started therapy with IFNβ-1a. Liver tests made prior to initiation of IFNβ-1a were normal but on admission to the Department exceed several times the upper limit. ALF was r...
Source: Polish Journal of Neurology and Neurosurgery - Category: Neurosurgery Source Type: research
More News: Corticosteroid Therapy | Jaundice | Liver | Multiple Sclerosis | Neurology | Urology & Nephrology