Recent trends in management of Alzheimer's disease: Current therapeutic options and drug repurposing approaches.

Recent trends in management of Alzheimer's disease: Current therapeutic options and drug repurposing approaches.
Curr Neuropharmacol. 2020 Jan 28;:
Authors: Singh RK
Abstract
Alzheimer's disease is one of the most progressive forms of dementia ultimately leading to death in aged populations. The major hallmarks of Alzheimer's disease include deposition of extracellular amyloid senile plaques and intracellular neurofibrillary tangles in brain neuronal cells. Although there are classical therapeutic options available for the treatment of the diseases, however they provide only a symptomatic relief and do not modify the molecular pathophysiological course of the disease. Recent research advances on Alzheimer's disease have highlighted a potential role of anti-amyloid, anti-tau and anti-inflammatory therapies. However, these therapies are still in different phases of pre-clinical/clinical development. In addition, drug repositioning/repurposing is another interesting and promising approach to explore rationalized options for treatment of Alzheimer's disease. This review discusses about the different aspect of pathophysiological mechanism involved in progression of Alzheimer's disease along with the limitations of the current therapies. Furthermore, this review also highlights emerging investigational drugs along with recent drug repurposing approaches for Alzheimer's disease.
PMID: 31989900 [PubMed - as supplied by publisher]

Source: Current Neuropharmacology - January 27, 2020 Category: Drugs & Pharmacology Authors: Singh RK Tags: Curr Neuropharmacol Source Type: research