HLA class II allele analyses implicate common genetic components in type 1 and non-insulin treated type 2 diabetes.

CONCLUSIONS: Genetic variation in the HLA class II locus exerts risk and protective effects on non-insulin treated type 2 diabetes. Our data suggest that the genetic architecture of type 1 diabetes and type 2 diabetes might share common components on the HLA class II locus.
PMID: 31974565 [PubMed - as supplied by publisher]

Source: The Journal of Clinical Endocrinology and Metabolism - January 23, 2020 Category: Endocrinology Authors: Jacobi T, Massier L, Klöting N, Horn K, Schuch A, Ahnert P, Engel C, Löffler M, Burkhardt R, Thiery J, Tönjes A, Stumvoll M, Blüher M, Doxiadis I, Scholz M, Kovacs P Tags: J Clin Endocrinol Metab Source Type: research