Investigation of the mechanism of action of Porana sinensis Hemsl. against gout arthritis using network pharmacology and experimental validation

ConclusionThe present study clarifies the mechanism of P. sinensis against GA, and provides evidence to support its clinical use.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research

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Robin shared her husband’s life-altering Wheat Belly experience: “I wanted to encourage those just starting out and getting through the difficult detox. If you are rethinking your decision, know that you are doing the best thing you could ever do for yourself and your family. “This is a picture of my husband, Kirk. He is 50 and had plans of having to go on disability this year due to the extreme pain in every joint in his body. Walking was extremely difficult. He works 10 hours a day in lawncare. We thought he had lupus or rheumatoid arthritis. Plus he suffered horrible gout attacks that would put him dow...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Open autoimmune gluten-free grain-free Inflammation Weight Loss wheat belly Source Type: blogs
In 1975, researchers from Yale investigated an epidemic of 51 patients with arthritis who lived near the woodsy town of Lyme, Connecticut. The most common symptom was recurrent attacks of knee swelling. A few had pain in other joints, such as the wrist or ankle. Many had fever, fatigue, and headache. Some remembered a round skin rash before the onset of knee swelling. We now know that Lyme disease is an infection acquired from tick bites, caused by a spiral bacterium named Borrelia burgdorferi. After a tick bite, Borrelia bacteria wriggle through the skin away from the bite site. This leads to a circular red rash, known as...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Arthritis Bones and joints Infectious diseases Source Type: blogs
Our body is flexible due the joints. These joints connect two bones, provide support and help in the body parts movement. Joint pain is a feeling of discomfort, aches and soreness in any of our body ’s joint. There have been lots of cases of people having aches in their joints. These joint pains are due to injuries affecting the ligaments, bursae, or tendons surrounding the joint. Pain in the joints is also due to infection and inflammation and in an extremely rare case because of cancer. It becomes extremely painful when you try to move your body parts suffering this pain.There are different conditions which are res...
Source: radRounds - Category: Radiology Authors: Source Type: blogs
When a drug is approved by the FDA, it may seem like it’s only a matter of time before some unexpected side effects are discovered. Perhaps it seems that way because it’s true! According to a study of all drugs approved between 2001 and 2010, the FDA announced alerts, warnings, or recalls on about one-third of them in the years after their approval. Some of the side effects were minor and easily managed. For example, there might be a warning to avoid taking a new medication at the same time as another medication. But sometimes the “side effect” is death. And that’s the case with a new warning ...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Drugs and Supplements Health Source Type: blogs
Elvira Sondo1, Roberta Bertelli2, Emanuela Pesce1, Gian Marco Ghiggeri2 and Nicoletta Pedemonte1* 1UOC Genetica Medica, IRCCS Istituto Giannina Gaslini, Genova, Italy 2UOC Nefrologia, IRCCS Istituto Giannina Gaslini, Genova, Italy Neutrophils migrate to sites of infection where they phagocytose, degranulate, and/or, in the presence of appropriate stimuli, release decondensed chromatin strands (called neutrophil extracellular traps, NETs) for trapping and possibly killing microorganisms. NET formation is characterized by marked morphological cell changes, in particular within the nucleus. Lytic NET formation can ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Authors: Harth M, Nielson WR Abstract INTRODUCTION: Most arthritides are associated with pain and psychological distress (clinically significant depression and anxiety). Pain and depression are mutually exacerbating; both may continue even when joint involvement appears well controlled. Area covered: There is strong evidence that arthritis-related stress impacts the central nervous system and, together with peripheral inflammatory changes, can cause central sensitization that can lead to chronic pain and worsening of affective distress. Cytokines and chemokines participate both in joint inflammation and in central ...
Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research
You're reading Natural Remedies That Help Relieve Your Joint Pain, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. If you are among millions of people suffering from joint pain and arthritis and living on pain-killers for quite a while, there is good news for you-you can have natural remedies to get rid of your pain. Whether you are facing stiffness, reduced the range of movements, and difficulty walking, there are certain natural therapies that are pretty much safer alternatives to taking drugs. According to the Centre ...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: health and fitness Joint pain natural remedies Source Type: blogs
You're reading Natural Remedies That Help Relieve Your Joint Pain?, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. If you are among millions of people suffering from joint pain and arthritis and living on pain-killers for quite a while, there is good news for you-you can have natural remedies to get rid of your pain. Whether you are facing stiffness, reduced the range of movements, and difficulty walking, there are certain natural therapies that are pretty much safer alternatives to taking drugs. According to the Centre...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: health and fitness Joint pain natural remedies Source Type: blogs
You're reading What Are The Best Natural Remedies That Help Relieve Your Joint Pain?, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. If you are among millions of people suffering from joint pain and arthritis and living on pain-killers for quite a while, there is good news for you-you can have natural remedies to get rid of your pain. Whether you are facing stiffness, reduced the range of movements, and difficulty walking, there are certain natural therapies that are pretty much safer alternatives to taking drugs. Accor...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: health and fitness Joint pain natural remedies Source Type: blogs
Rationale: Rheumatoid arthritis (RA) and gout are common rheumatic diseases. However, their coexistance has been rarely reported. Here in, we describe a case of a middle aged Chinese woman having RA complicated with atypical gout on both the knee joints. Patient concerns: A 44-year-old Chinese woman complained of swelling and tenderness of multiple joints since 10 months. She had a positive rheumatoid factor and high titers of anti-CCP antibody. She was diagnosed with RA, and commenced on methotrexate, leflunomide, and methylprednisolone. Her symptoms of pain and swelling over interphalangeal and wrists joints subside...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
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