Cancer causes metabolic perturbations associated with reduced insulin-stimulated glucose uptake in peripheral tissues and impaired muscle microvascular perfusion

Redirecting glucose from skeletal muscle and adipose tissue, likely benefits the tumor ’s energy demand to support tumor growth, as cancer patients with type 2 diabetes have 30% increased mortality rates. The aim of this study was to elucidate tissue-specific contributions and molecular mechanisms underlying cancer-induced metabolic perturbations.

Source: Metabolism - Clinical and Experimental - January 23, 2020 Category: Biomedical Science Authors: Xiuqing Han, Steffen H. Raun, Michala Carlsson, Kim A. Sj øberg, Carlos Henriquez-Olguín, Mona Ali, Annemarie Lundsgaard, Andreas M. Fritzen, Lisbeth L.V. Møller, Zhen Li, Jinwen Li, Thomas E. Jensen, Bente Kiens, Lykke Sylow Source Type: research