18 a human-derived 5-mer peptide (mtadv), which restrictively alleviates the pro-inflammatory activity of serum amyloid a (saa), substantially ameliorates ibd pathology: new potential drug (mtadv) and therapeutic target candidate (saa) for ibd

A human anti-inflammatory 5-MER peptide MTADV (methionine-threonine-alanine-aspartic acid-valine) derived from a sequence of a pro-inflammatory CD44 variant was first described by us in Nedvetzki et  al., J. Clin. Invest. 111,1211-1220, 2003. A NCBI BLAST RefSeq protein sequence database, that contains at present 81,347 human protein sequences, reveals that only one additional protein contains this unique MTADV sequence of alternating hydrophobic and hydrophilic amino acids. This human peptide displays an efficient anti-inflammatory effect in Inflammatory Bowel Disease (IBD), Rheumatoid Arthritis and Multiple sclerosis mouse models, all share amyloid proteins in the relevant target organs.

Source: Gastroenterology - January 25, 2020 Category: Gastroenterology Authors: David Naor, Maayan Hemed-Shaked, Mary Cowman, Jin Kim, Jordi Armengol, Jorge Alemany, Darja Kanduc Tags: Animal Models: Pre-Clinical Treatment of Intestinal Inflammation Source Type: research