Viruses, Vol. 12, Pages 137: SV40 Large T Antigen Is Not Responsible for the Loss of STING in 293T Cells but Can Inhibit cGAS-STING Interferon Induction

This study also revealed that SV40 LT does indeed inhibit cGAS-STING interferon induction, but through a mechanism distinct from other DNA virus oncogenes. Collectively, these results indicate that while SV40 LT can inhibit cGAS-STING interferon induction, it does so in an unanticipated manner.

Source: Viruses - January 23, 2020 Category: Virology Authors: Reus Trivino-Soto Wu Kokott Lim Tags: Article Source Type: research