Sustained Donor Chimerism and Rapid Immune Cell Reconstitution with a Low Probability of Gvhd Following Familial Haploidentical (FHI) CD34 Enriched Stem Cell Transplantation with Pbmnc Addback in Patients with High Risk Sickle Cell Disease (SCD) (IND 14359)

We reported a very low incidence of GVHD in pediatric recipients receiving CD34 enriched HPC products with PBMNC addback from MUD donors (Geyer/Cairo et al, BJH, 2012). Rapid NK cell reconstitution after AlloSCT is associated with a significant improvement in 1yr OS (Pical-Izard, BBMT, 2015).

Source: Biology of Blood and Marrow Transplantation - January 24, 2020 Category: Hematology Authors: Yaya Chu, Julie-An M. Talano, Lee Ann Baxter-Lowe, Erin Morris, Harshini Mahanti, Janet Ayello, Carolyn A. Keever-Taylor, Bryon D. Johnson, Rona S. Weinberg, Qiuhu Shi, Theodore B. Moore, Sandra Fabricatore, Brenda Grossman, Carmella van de Ven, Shalini S Tags: 463 Source Type: research