Improved Outcomes of Transplant Associated Thrombotic Microangiopathy with Early Initiation of Eculizumab

Transplant-associated thrombotic microangiopathy (TA-TMA) is a rare, potentially lethal complication of allogeneic stem cell transplant. It is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and renal dysfunction. Endothelial injury and terminal complement activation contribute to the pathogenesis of TA-TMA. Several risk factors have been identified including certain conditioning regimens, acute graft versus host disease (GvHD) and/or calcineurin inhibitors (CNI), and viral infections.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: 181 Source Type: research