Sustained Immunogenic and Clinical Effects of Low-Dose Interleukin-2 Therapy with an Intermittent Maintenance Method for Refractory Chronic Graft-Versus-Host Disease: Results of Phase1/2a LDIL2-01 Study

Regulatory T cells (Treg) play a central role in the maintenance of immune tolerance. We previously reported that the altered Treg homeostasis in the prolonged lymphopenia after HSCT is one of the major pathogenesis of impaired Treg recovery leading to the onset of chronic GVHD and low-dose IL-2 can restore normal Treg homeostasis by a PD-1-dependent mechanism, resulting in the improvement of clinical GVHD symptoms. In these years, the tolerogenic effects of IL-2 have been tested for various autoimmune diseases by clinical trials.

Source: Biology of Blood and Marrow Transplantation - January 24, 2020 Category: Hematology Authors: Yusuke Meguri, Kazuteru Ohashi, Yoshihiro Inamoto, Satoshi Iyama, Chikako Ohwada, Makoto Murata, Atsushi Satake, Yasuo Mori, Koichi Nakase, Chikamasa Yoshida, Noriko Doki, Yuho Najima, Tetsuya Nishida, Yoshinobu Maeda, Ken-ichi Matsuoka Tags: 256 Source Type: research