Boosting Transdermal delivery of Atorvastatin Calcium via o/w Nanoemulsifying System: Two-step optimization, ex vivo and in vivo evaluation

In conclusion, data revealed no correlation between ex vivo and in vivo studies explained by the collapse of the follicles in ex vivo skin permeation study, leaving only the lipoidal pathway for NE to pass through, thus only NE components, neither nanosizing nor other reported mechanisms, are the main influencing factors. In vivo experiments suggested that o/w NE changed ATOR pathway to follicular delivery leading to accumulation of NE in follicles and consequently a prolonged plasma profile.Graphical abstract
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research

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Clinical Liver Disease, Volume 15, Issue 1, Page 40-45, January 2020.
Source: Clinical Liver Disease - Category: Gastroenterology Authors: Tags: Review Source Type: research
Purpose of review To review the recent evidence from observational/genetic/interventional studies addressing triglycerides and residual cardiovascular risk (CVRisk). Recent findings Large population-based and secondary prevention studies consistently show an association of higher triglycerides with increased CVRisk. This is compounded by genetic studies demonstrating an independent relationship between triglyceride raising or lowering genetic variants affecting triglyceride-rich lipoproteins (TRL) metabolism and CVRisk. Mendelian randomization analysis suggests the benefit of genetic lowering of triglycerides and LDL-...
Source: Current Opinion in Endocrinology, Diabetes and Obesity - Category: Endocrinology Tags: LIPIDS: Edited by Dan Streja Source Type: research
The pairing of two LDL-C-lowering agents called Nexlizet is indicated for use on top of statins to help adults with established ASCVD or heterozygous familial hypercholesterolemia reach their goals.FDA Approvals
Source: Medscape Cardiology Headlines - Category: Cardiology Tags: Cardiology News Alert Source Type: news
CONCLUSIONS: Heterozygous FH is associated with increased risk for stroke, PAD and AoVC. Clinicians should take these non-CHD ASCVD aspects into consideration for optimal management of FH patients. PMID: 32096673 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
An electronic algorithm was used to flag patients with HCV risk markers for testing Related items fromOnMedica Widespread hepatitis C screening may do more harm than good Earlier transplants for liver disease kids may cut brain damage risk Significant fall in Hepatitis C deaths Doctors urge government to act on rising alcohol impact Benefits of statins 'still outweigh risks'
Source: OnMedica Latest News - Category: UK Health Source Type: news
Publication date: Available online 26 February 2020Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Ben Ponvilawan, Nipith Charoenngam, Thanitsara Rittiphairoj, Patompong Ungprasert
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
No abstract available
Source: American Journal of Clinical Oncology - Category: Cancer & Oncology Tags: Editorial Source Type: research
CONCLUSIONS: Statin therapy was more effective in reducing the cumulative risks of MACE, all-cause death, and TVR in the STEMI group than NSTEMI group in Korean patients with AMI after successful drug-eluting stent implantation. PMID: 32089157 [PubMed - in process]
Source: The American Journal of the Medical Sciences - Category: General Medicine Authors: Tags: Am J Med Sci Source Type: research
Data on statin use and risk of multiple myeloma is still conflicting. We performed a systematic review that comprised of terms for “statin” and “multiple myeloma” and identified 10 eligible studies for meta-analysis. The risk of multiple myeloma was significantly lower among statin-users than non-users with the pooled odds ratio of 0.80 (95% CI, 0.68 – 0.93; I2 = 72%).
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Original Study Source Type: research
Conclusion: It seems that patients with chronic kidney disease could receive statin treatment to reduce the occurrence of newly diagnosed sarcopenia. Additionally, a higher dosage of statins could reduce the incidence of newly diagnosed sarcopenia in patients with chronic kidney disease.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
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