Dr. Laura E. Nagy to Deliver 24th Annual Mark Keller Honorary Lecture at the National Institutes of Health

What:The National Institute on Alcohol Abuse and Alcoholism (NIAAA), part of the National Institutes of Health, announces that Laura E. Nagy, Ph.D., will deliver the 24th Annual Mark Keller Honorary Lecture. The title of her presentation is “Inflammation and Cell Death in Alcohol-Associated Liver Disease.”  
Source: NIAAA News - Category: Addiction Authors: Source Type: news

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Publication date: Available online 9 July 2020Source: Journal of the Formosan Medical AssociationAuthor(s): Yen-Ying Chen, Matthew M. Yeh
Source: Journal of the Formosan Medical Association - Category: General Medicine Source Type: research
(Flinders University) Alcohol's popularity and its central place in socialising in Australia obscures the dangers of excessive drinking and possible liver disease, Flinders University experts warn. As Dry July awareness month highlights the various health risks, the Head of Hepatology and Liver Transplantation at Flinders Medical Centre Associate Professor Alan Wigg says alcohol misuse remains a major health challenge in Australia as seen by high in rates of life-threatening liver disease.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news
Authors: Dutra JDM, Lisboa QC, Ferolla SM, Carvalho CMML, Mendes CCM, Ferrari TCA, Couto CA Abstract Some epidemiological evidence suggests an inverse correlation between non-alcoholic fatty liver disease (NAFLD) frequency and vitamin D levels. Likewise, a beneficial effect of vitamin D on diabetes mellitus (DM) and insulin resistance has been observed, but this is an unsolved issue. Thus, we aimed to investigate the prevalence of hypovitaminosis D in a NAFLD Brazilian population and its association with disease severity and presence of comorbidities. In a cross-sectional study, the clinical, biochemical and histo...
Source: International Journal for Vitamin and Nutrition Research - Category: Nutrition Tags: Int J Vitam Nutr Res Source Type: research
Condition:   NAFLD Intervention:   Other: Gut microbiome transplantation Sponsors:   Leiden University Medical Center;   Dutch Donor Feces Bank;   Vedanta Biosciences Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Fatty Liver;   NAFLD Intervention:   Other: exercise Sponsor:   National Taiwan University Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   NAFLD Intervention:   Other: Gut microbiome transplantation Sponsors:   Leiden University Medical Center;   Dutch Donor Feces Bank;   Vedanta Biosciences Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Fatty Liver;   NAFLD Intervention:   Other: exercise Sponsor:   National Taiwan University Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Abstract The review is withdrawn on 09.07.2020, as it has not been updated since its first publication in 2007. PMID: 32645206 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
Condition:   Nonalcoholic Steatohepatitis Intervention:   Sponsor:   University of California, San Diego Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Abstract LRH-1 is a nuclear receptor that regulates lipid metabolism and homeostasis, making it an attractive target for the treatment of diabetes and non-alcoholic fatty liver disease. Building on recent structural information about ligand binding from our labs, we have designed a series of new LRH-1 agonists that further engage LRH-1 through added polar interactions. While the current synthetic approach to this scaffold has, in large part, allowed for decoration of the agonist core, significant variation of the bridgehead substituent is mechanistically precluded. We have developed a new synthetic approach to ove...
Source: Bioorganic and Medicinal Chemistry Letters - Category: Chemistry Authors: Tags: Bioorg Med Chem Lett Source Type: research
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