Human B cells infected by Trypanosoma cruzi undergo F-actin disruption and cell death via caspase-7 activation and cleavage of phospholipase C γ1.

Human B cells infected by Trypanosoma cruzi undergo F-actin disruption and cell death via caspase-7 activation and cleavage of phospholipase Cγ1. Immunobiology. 2020 Jan 16;:151904 Authors: Dos Santos MA, Alves Martins F, Borges BC, de Gouveia Santos J, Nascimento Alves R, Dias MH, BrígidoTavares PC, E Silva Brígido RT, Teixeira TL, Costa Rodrigues C, Cota Teixeira S, da Costa MS, da Silva AA, Barbosa Silva MJ, de Melo Rodrigues Ávila V, Patriarca Mineo TW, de Souza MA, Bahia D, da Silva CV Abstract B cells contribute to the immune system in many ways such as antigen presentation to CD4+ T cells, secretion of cytokines and lymphoid tissue organogenesis. Furthermore, they are the only cell type capable of producing immunoglobulins. B cells also account for critical aspects of the resistance against intracellular pathogens. Trypanosoma cruzi is an intracellular parasite that sabotages humoral response by depletion of immature B cells. Polyclonal activation and secretion of non-specific antibodies are also other mechanisms used by T cruzi to evade and subvert the mammalian host immune system, leading to increased parasitemia and susceptibility to Chagas' disease. It remained unclear whether B cell depletion occurs due to direct contact with T. cruzi or results from a global increase in inflammation. Unlike previous reports, we demonstrated in this study that T. cruzi infects human B cells, resulting in parasite-induced activation of...
Source: Immunobiology - Category: Allergy & Immunology Authors: Tags: Immunobiology Source Type: research