Contextual risk among adolescents receiving opioid prescriptions for acute pain in pediatric ambulatory care settings.

Contextual risk among adolescents receiving opioid prescriptions for acute pain in pediatric ambulatory care settings. Addict Behav. 2020 Jan 11;104:106314 Authors: Dash GF, Feldstein Ewing SW, Murphy C, Hudson KA, Wilson AC Abstract Many adults with opioid use disorder (OUD) report that their first exposure to opioids was in the course of routine pain treatment in medical care settings. Adolescents receive opioid prescriptions with frequency, but are susceptible to a constellation of unique risks in the context of pain management. This empirical study presents the first cohort of adolescents recruited from ambulatory medical care within 72 h of their receipt of opioids to treat acute pain. The primary aim was to capture a time-sensitive report of the intersection of prescription opioid receipt and contextual risks for opioid misuse related to pain experience, mental health symptoms, and substance use at the adolescent and parental levels. Data were collected from 70 14-19-year-old adolescents and their accompanying parent. Results reflected that 90% of this sample of adolescents reported 2 or more risks and 35% reported 5 or more risks for future opioid misuse. Pain catastrophizing (46%) and alcohol use (40%) and were the most common adolescent-level risk factors; mother history of chronic pain (32%) and parent anxiety (21%) were the most common parent-level risk factors. Past-week parent pain intensity showed the strongest association with adolesc...
Source: Addictive Behaviors - Category: Addiction Authors: Tags: Addict Behav Source Type: research

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The opioid crisis is known as the health crisis surrounding prescription, and nonprescription, opioid drugs. The overdose and death rates of opioids are climbing exponentially and the use of the drug is more rampant now than ever. How Did the Opioid Crisis Begin? In the late 1990s, pharmaceutical companies reassured the medical community that patients would not become addicted to prescription opioid pain relievers, and healthcare providers began to prescribe them at greater rates. Before long, this lead to the medications becoming misused and it became apparent that these medications were indeed highly addictive. However,...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Addiction Addiction to Pharmaceuticals Heroin Addiction Recovery opioid opioid crisis opioids pharmaceutical addiction pharmaceutical drug abuse treatment pharmacists Source Type: blogs
Conclusion and Future Directions G protein bias may either be affinity/potency-dominant or efficacy-dominant (Table 1). A potential concern is that, despite using the same cellular assays, variations in agonist potency were determined by different, or even the same labs, potentially due to differences in expression levels of the receptor and signaling proteins that occurred during cell passaging. For example the reported arrestin recruitment potency for U69,593 has been reported to be as low as 67.7 nM (Spetea et al., 2017) and as high as 410 nM (Dunn et al., 2018), similarly for U50,488 potency has ranged from 36 to 1000...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Ryan R. Kelly1,2†, Lindsay T. McDonald1,2†, Nathaniel R. Jensen1,2, Sara J. Sidles1,2 and Amanda C. LaRue1,2* 1Research Services, Ralph H. Johnson VA Medical Center, Charleston, SC, United States 2Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, United States The significant biochemical and physiological effects of psychological stress are beginning to be recognized as exacerbating common diseases, including osteoporosis. This review discusses the current evidence for psychological stress-associated mental health disorders as risk factors for os...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
What is a Benzodiazepine? Benzodiazepines are a prescription drug sedative used to treat a variety of conditions. They are classified as Schedule IV in the Controlled Substances Act. Some of the conditions that Benzodiazepine can treat include: Insomnia Anxiety Seizures Muscle tension Panic disorders When used as prescribed under the supervision of a medical professional, Benzodiazepines can be very useful in the treatment of these disorders. Many people are able to live healthy, happy lives while taking Benzodiazepines to curb the symptoms of their various conditions. However, because of the addictive nature of Benzodia...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Uncategorized benzo benzodiazepines prescription drug abuse prescription drug addiction prescription drug use prescription pills Source Type: blogs
 Former Congressman Patrick Kennedy joins our hosts to talk about mental health and addiction parity, both at the federal and state levels. He shares information about new initiatives, dontdenyme.org and parityregistry.org, designed to help consumers file appeals on their own, if they feel they’ve been wrongly denied coverage by their insurance companies. They speak candidly about the problems faced with regard to parity by those who live with mental health or addiction issues. And finally, they talk about how anyone can become an advocate. Subscribe to Our Show! And Remember to Review Us! About O...
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Much of what we think we know about cannabis may soon change as a result of new research that uncovers some surprising facts. Indeed, the topic, which can be emotionally charged, is the focus of intense scientific study. Is cannabis good for you? Is it addictive? What long-term harms can use cause? The answers to these questions are multi-layered and not always clear-cut, which is why cannabis research continues with even more urgency. FACTS ON CANNABIS ADDICTION AND DEPENDENCE Current estimates are that one in 10 cannabis users will develop cannabis addiction or dependence. The potency of the delta-9-tetrahydrocannabinol ...
Source: Psych Central - Category: Psychiatry Authors: Tags: Addictions Habits Healthy Living Memory and Perception Miscellaneous Drugs Neuroscience Substance Abuse Source Type: news
Our Approach Cliffside Malibu is a world class luxury drug and alcohol treatment center. We want you to recover for good, and we do that with seven major factors. 1. We Stand By Our Commitment To Your Success. Our main goal is: We only want you to come to treatment once. 2. We Recognize The Root Cause Of Addiction As Pain/Trauma. Most treatment programs are based on the 12 Step Model. While 12 Step programs have largely been the go-to way to recover from addiction for over 75 years, the model does not address the underlying causes of addiction. While we use 12 Steps as an adjunct to other forms of therapy, we work to help ...
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Conclusion. A review of the literature suggests that there are adequate data supporting the efficacy and general safety of the low-dose use of trazodone for the treatment of insomnia. keywords: insomnia, hypnotics, treatment, trazodone, sedative Keywords: insomnia, hypnotics, treatment, trazodone, sedative Innov Clin Neurosci. 2017;14(9–10):24–34 Introduction Insomnia is characterized by difficulty falling asleep, difficulty staying asleep, or waking too early1 and is associated with significant impairments in daytime activities, which might occur despite adequate opportunities for sleep.2–6 Primary insom...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Current Issue Review hypnotics insomnia sedative trazodone treatment Source Type: research
The prescription opioid crisis of overdosing and overprescribing has reached epic proportions, according to the North American media. Just last week, we learned that 91% of patients who survive opioid overdose are prescribed more opioids! The CDC calls it an epidemic, and notes there's been “a 200% increase in the rate of overdose deaths involving opioid pain relievers and heroin.” A recent paper in the Annual Review of Public Health labels it a “public health crisis” and proposes “interventions to address the epidemic of opioid addiction” (Kolodny et al., 2015).In the midst of this publ...
Source: The Neurocritic - Category: Neuroscience Authors: Source Type: blogs
Pain. It’s a nearly unavoidable part of the human experience. Whether it comes as the result of an injury or accident, surgery, or a health issue such as a headache or infection, arthritis, or fibromyalgia, pain can interfere with the ability to sleep, work, and enjoy life. There are many ways to treat pain. Opioid drugs are one of them. Some examples include hydrocodone (used in Vicodin), oxycodone (used in Percocet), methadone, codeine, and morphine. These prescription drugs reduce the brain’s recognition of pain by binding to certain receptors in the body. In many situations, opioids are a reasonable choice ...
Source: New Harvard Health Information - Category: Consumer Health News Authors: Tags: Addiction Drugs and Supplements Pain Management naloxone narcan opioids painkillers prescription painkillers Source Type: news
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