Identification of cartilage microbial DNA signatures and associations with knee and hip osteoarthritis

ConclusionsOur study reveals a microbial DNA signature in human and mouse cartilage. We find alterations in this signature, including increases in Gram ‐negative constituents, during the development and progression of human OA. Furthermore, we identified strain‐specific signatures within mouse cartilage that mirror human patterns. The establishment and potential pathogenic role of these DNA signatures deserve further study.

https://onlinelibrary.wiley.com/doi/abs/10.1002/art.41210?af=R

Source: Arthritis and Rheumatology - January 20, 2020 Category: Rheumatology Authors: Christopher M. Dunn, Cassandra Velasco, Alexander Rivas, Madison Andrews, Cassandra Garman, Paul B. Jacob, Matlock A. Jeffries Tags: FULL LENGTH Source Type: research