Chemokine profile in Alzheimer’s disease: Results from a Mexican population

Publication date: Available online 20 January 2020Source: Journal of Clinical NeuroscienceAuthor(s): Fernando Gongora-Rivera, Alejandro Gonzalez-Aquines, Xóchitl Ortiz-Jiménez, Carlos Medina de la Garza, Mario Salinas-CarmonaAbstractAlzheimer’s Disease (AD) is the main cause of dementia worldwide. Inflammatory cytokines and chemokines are related to different stages of AD and may be related to the progression of the disease. A Case-control study of AD patients healthy, age and sex-matched controls was carried out at the University Hospital “Dr. José E. Gonzalez”, UANL. Cytokines and chemokines were measured from blood samples taken from the cubital vein after 8 h of fast. We included 78 subjects from which 29 had AD and 49 were healthy controls. CTACK (p = 0.003), MIG (p = 0.043) and SDF-1α (p = 0.001) were increased in subjects with AD, whereas no change was observed in other cytokines and chemokines. CTACK, MIG and SDF-1α are present in the Central Nervous System and are related to inflammation and endothelial dysfunction. Longitudinal studies evaluating the change of these chemokines in AD are needed to understand their role in AD progression and possibly lead to new diagnostic and therapeutic targets.
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research

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Date: Tuesday, 03 24, 2020; Speaker: Dr. Allison Snyder, NINDS; Dr. Bruce Miller, University of California San Francisco; Building: Building 10 (Clinical Center); Lipsett Auditorium; CME Credit
Source: NIH Calendar of Events - Category: American Health Source Type: events
CONCLUSIONS: Limited evidence suggests the CAC score is associated with risk of dementia. In clinical CAD, risk of MCI and dementia is increased by 50%, as supported by stronger evidence. PMID: 32062643 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - Category: Cardiology Tags: J Atheroscler Thromb Source Type: research
Authors: Baldacci F, Mazzucchi S, Della Vecchia A, Giampietri L, Giannini N, Maya KH, Ceravolo R, Siciliano G, Bonuccelli U, Elahi FM, Vergallo A, Lista S, Giorgi FS, Hampel H Abstract Introduction: The post-mortem examination still represents the reference standard for detecting the pathological nature of chronic neurodegenerative diseases (NDD). This approach displays intrinsic conceptual limitations since NDD represent a dynamic spectrum of partially overlapping phenotypes, shared pathomechanistic alterations that often give rise to mixed pathologies.Areas covered: We scrutinized the international clinical diagn...
Source: Expert Review of Molecular Diagnostics - Category: Laboratory Medicine Tags: Expert Rev Mol Diagn Source Type: research
CONCLUSION: With up to 90% of PWD moving into formal care before they die in some countries, governments and other service providers of formal care need to provide culturally congruent care. There is also a need to build relationships with minority social groups that are not cared for by geriatric service organisations (governmental and non-governmental) in order to break down the negative attitudes that families have about formal care, and provide the families caring for PWD at home with coping strategies and support programmes to enhance the caregiving experience. PMID: 32069454 [PubMed - as supplied by publisher]
Source: Dementia and Geriatric Cognitive Disorders - Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research
CONCLUSIONS: Brain 18F-FDG PET had an elevated performance in the early diagnosis of PPA variants and in the advanced PPA AD/FTD classification. QL clarified the development of AD or FTD in advanced PPA cases and supported the differential diagnosis of a PPA variant in a few early cases. QN 18F-FDG PET evaluation better contributed to the early diagnosis of an unclear metabolic pattern. To correctly identify all cases, patients with diffuse cortical hypometabolism were also included. Larger series are necessary to confirm these data. PMID: 32062656 [PubMed - as supplied by publisher]
Source: Dementia and Geriatric Cognitive Disorders - Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research
Authors: Xiong C, Luo J, Coble D, Agboola F, Kukull W, Morris JC Abstract INTRODUCTION: We aim to determine racial disparities and their modifying factors in risk for Alzheimer's disease (AD) dementia among cognitively normal individuals 65 years or older. METHODS: Longitudinal data from the National Alzheimer's Coordinating Center Uniform Data Set on 1229 African Americans (AAs) and 6679 whites were analyzed for the risk of AD using competing risk models with death as a competing event. RESULTS: Major AD risk factors modified racial differences which, when statistically significant, occurred only with olde...
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
Source: Neuropsychiatric Disease and Treatment - Category: Psychiatry Tags: Neuropsychiatric Disease and Treatment Source Type: research
Authors: Barata AN Abstract Globally, the world population is ageing, which increases the prevalence of non-communicable diseases that affect patients both physically and psychologically, such as is the case of dementia. Consequently, there is a greater demand for the healthcare system as it needs to develop solutions to answer to these needs.The literature review shows that complementary therapies may be applied in dementia in order to aid the symptom management as well as to slow down the progression of the disease. The Socially Assistive Robots (SAR) are tools that may be used as a complementary therapy in demen...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Publication date: 18 February 2020Source: Cell Reports, Volume 30, Issue 7Author(s): Helen M. Melo, Gisele da S. Seixas da Silva, Marcella Ramos Sant’Ana, Camila Vieira Ligo Teixeira, Julia R. Clarke, Vivian S. Miya Coreixas, Bruno C. de Melo, Juliana T.S. Fortuna, Leticia Forny-Germano, José Henrique Ledo, Maíra S. Oliveira, Claudia P. Figueiredo, Raphaelle Pardossi-Piquard, Frédéric Checler, José María Delgado-García, Agnès Gruart, Licio A. Velloso, Marcio L.F. Balthazar, Dennys E. Cintra, Sergio T. FerreiraSummaryObesity has been associated with cognitive dec...
Source: Cell Reports - Category: Cytology Source Type: research
Conditions:   Age-related Macular Degeneration;   Dementia;   Low Vision;   Low Vision Aids;   Hearing Loss;   Reading Problem;   Cognitive Impairment Intervention:   Behavioral: Low Vision Reading Rehabilitation Sponsors:   Université de Montréal;   Fonds de la Recherche en Santé du Québec;   Canadian Institutes of Health Research (CIHR) Recruiting
Source: - Category: Research Source Type: clinical trials
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