Accelerative effects of carbazole-type alkaloids from Murraya koenigii on neurite outgrowth and their derivative ’s in vivo study for spatial memory

AbstractMurraya koenigii is a medicinal plant that contains several carbazole-type alkaloids as its characteristic constituents. Blood –brain barrier permeable constituents ofM. koenigii accelerated neurite outgrowth in PC-12 cells. Nine compounds were isolated fromM. koenigii and their effects on neurite outgrowth were examined. Murrayamine-E (8) at 10  μM showed significant effect. Focusing on the carbazole skeleton, we synthesized derivatives to attenuate cytotoxicity. 9-Benzyl-9H-carbazol-4-ol (15) exhibited strong neurite outgrowth accelerative effect. In addition, the novel object recognition test and the Morris water maze test were performed to evaluate memory improvement of15 in APdE9 mice. Compound15 tended to improve spatial memory in the Morris water maze test. These results suggest that carbazole derivative15 would be a seed compound for Alzheimer ’s disease drug.
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research