White matter microstructural organizations in patients with severe treatment-resistant schizophrenia: A diffusion tensor imaging study

Publication date: Available online 18 January 2020Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Ryo Ochi, Yoshihiro Noda, Shohei Tsuchimoto, Ryosuke Tarumi, Shiori Honda, Karin Matsushita, Sakiko Tsugawa, Eric Plitman, Fumi Masuda, Kamiyu Ogyu, Masataka Wada, Takahiro Miyazaki, Shinya Fujii, M. Mallar Chakravarty, Ariel Graff-Guerrero, Hiroyuki Uchida, Masaru Mimura, Shinichiro NakajimaAbstractPrevious diffusion tensor imaging (DTI) studies have reported white matter alterations in patients with schizophrenia. Notably, one third of this population does not respond to first-line antipsychotics and is thus referred to as treatment-resistant schizophrenia (TRS). Despite potentially distinct neural bases between TRS and non-TRS, few studies have compared white matter integrity between these groups. In order to reflect clinical picture of TRS, we enrolled TRS patients who had severe symptoms. According to the consensus criteria for TRS. TRS was defined by severe positive symptomatology despite optimal antipsychotic treatment. Fractional anisotropy (FA), an index of white matter integrity, was examined by DTI and analyzed with tract-based spatial statistics in 24 TRS patients (mean PANSS = 108.9), 28 non-TRS patients (mean PANSS = 50.0), and 27 healthy controls (HCs) for group comparison. Additionally, correlation analyses were conducted between FA values and symptomatology. The TRS group had lower FA values in multiple tracts (cerebral pe...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research

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Authors: Chow TJ, Tee SF, Loh SY, Yong HS, Abu Bakar AK, Tang PY PMID: 32078952 [PubMed - as supplied by publisher]
Source: Asian Journal of Psychiatry - Category: Psychiatry Tags: Asian J Psychiatr Source Type: research
Publication date: Available online 21 February 2020Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Sergej Nadalin, Suzana Jonovska, Vesna Šendula Jengić, Alena Buretić-TomljanovićABSTRACTThe available data suggest that abnormalities of arachidonic acid-related signaling may be of relevance in attenuated niacin-induced flush responses and lipid and glucose metabolism disturbances, which are all common among individuals with schizophrenia. We previously demonstrated attenuated skin flush responses to niacin in patients with schizophrenia. Here we investigated whether these niacin responses ...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - Category: Lipidology Source Type: research
In this non-interventional study, the functionality and well-being of patients with schizophrenia with aripiprazole once-monthly (AOM) was evaluated under real-life conditions in a naturalistic population.
Source: BMC Psychiatry - Category: Psychiatry Authors: Tags: Research article Source Type: research
AbstractPoor mental health remains a significant source of morbidity and mortality in the Bhutanese refugee community. Mental Health First Aid (MHFA) is a promising intervention that has been used in other immigrant communities to prepare individuals to recognize and respond to mental health warning signs. This was a non-randomized program evaluation. Using pre- and post-training questionnaires developed for prior evaluations of MHFA, we examined the effectiveness of training offered with and without culturally-appropriate orientation to mental health terminology and concepts (N  = 458). Pre- to post-training...
Source: Journal of Immigrant and Minority Health - Category: International Medicine & Public Health Source Type: research
ConclusionData revealed a gap between concepts and emotional and cognitive experiences. Both professional and experiential language and knowledge have to be considered as complementary. Consequently, the ICD should be co-constructed by professionals, service users, and carers. It should take the emotional component of language, and the diversity of linguistic and cultural contexts, into account.
Source: Social Psychiatry and Psychiatric Epidemiology - Category: Psychiatry Source Type: research
Publication date: August 2020Source: New Ideas in Psychology, Volume 58Author(s): Giampaolo Salvatore, Paolo Ottavi, Raffaele Popolo, Giancarlo DimaggioAbstractAuditory verbal hallucinations (AVHs) are perceptive-like experiences happening without appropriate stimuli that in individuals with schizophrenia very often feature distressing contents. AVH frequently interfere with social relationships or result in dangerous behaviours. We hypothesize that in schizophrenia several vulnerability factors, especially when a subject is engaged in real or represented interpersonal transactions, lead to the appearance of AVHs, and favo...
Source: New Ideas in Psychology - Category: Psychiatry & Psychology Source Type: research
Conditions:   Quality of Life;   Well-Being;   Compliance, Treatment Intervention:   Behavioral: Group Psychoeducation that Focused on Social Skill Development Sponsor:   Gazi University Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Schizophrenia;   Learning Disorders;   Executive Function Disorders Interventions:   Diagnostic Test: Standardised semi-structured talk;   Diagnostic Test: Autistic spectre disorder screening;   Diagnostic Test: Anxiety measuring Sponsor:   Assistance Publique - Hôpitaux de Paris Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Quality of Life;   Well-Being;   Compliance, Treatment Intervention:   Behavioral: Group Psychoeducation that Focused on Social Skill Development Sponsor:   Gazi University Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Schizophrenia;   Learning Disorders;   Executive Function Disorders Interventions:   Diagnostic Test: Standardised semi-structured talk;   Diagnostic Test: Autistic spectre disorder screening;   Diagnostic Test: Anxiety measuring Sponsor:   Assistance Publique - Hôpitaux de Paris Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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