Actions of 17β-Estradiol and Testosterone in the Mitochondria and their Implications in Aging.
Actions of 17β-Estradiol and Testosterone in the Mitochondria and their Implications in Aging.
Ageing Res Rev. 2013 Sep 13;
Authors: Vasconsuelo A, Milanesi L, Boland R
Abstract
A decline in the mitochondrial functions and aging are two closely related processes. The presence of estrogen and androgen receptors and hormone-responsive elements in the mitochondria represents the starting point for the investigation of the effects of 17β-estradiol and testosterone on the mitochondrial functions and their relationships with aging. Both steroids trigger a complex molecular mechanism that involves crosstalk between the mitochondria, nucleus, and plasma membrane, and the cytoskeleton plays a key role in these interactions. The result of this signaling is mitochondrial protection. Therefore, the molecular components of the pathways activated by the sexual steroids could represent targets for anti-aging therapies. In this review, we discuss previous studies that describe the estrogen- and testosterone-dependent actions on the mitochondrial processes implicated in aging.
PMID: 24041489 [PubMed - as supplied by publisher]
Source: Ageing Research Reviews - Category: Genetics & Stem Cells Authors: Vasconsuelo A, Milanesi L, Boland R Tags: Ageing Res Rev Source Type: research