4-in-1 phototheranostics: PDA@CoPA-LA nanocomposite for photothermal imaging/photothermal/in-situ O2 generation/photodynamic combination therapy

Publication date: 1 May 2020Source: Chemical Engineering Journal, Volume 387Author(s): Zheng Yang, Xinyu Liu, Xueyan Wang, Pengcheng Wang, Shanshan Ruan, Anjian Xie, Yuhua Shen, Manzhou ZhuAbstractPhototherapy is an important branch in the application of cancer therapy, having the advantages of low invasion, negligible toxicity, and convenience, which are rapidly developing in the pre-clinic and clinic therapy for cancer. Herein, a novel multifunctional nanocomposite containing polydopamine (PDA)@cobalt phytate (CoPA) with lactose acid (LA) grafting were successfully synthesized. The PDA core was used as the template for the formation of CoPA, and also endowed the obtained nanocomposite with photothermal imaging and photothermal therapy (PTT) to cancers. The CoPA shell possessed excellent dual photo-responsive abilities, not only induced the formation of singlet oxygen, but also catalyzed intracellular water-splitting to produce O2 in situ for enhancing photodynamic therapy (PDT) effect on tumor cells under laser irradiation. Furthermore, the lactose acid grafting endued the targeting ability to the synthesized nanocomposites for realizing specific targeted cancer therapy. The experiment results in vitro and in vivo both demonstrate that the designed PDA@CoPA-LA NCs have excellent synergistic PTT and PDT effect enhanced by in situ O2-generation with specific targeted performance, exhibiting great potential in the application for clinic cancer therapy.Graphical abstract
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research