Gingival papillomatosis as the oral sign of Cowden ' s syndrome. A case report.

AbstractCowden ' s syndrome (CS) is a rare autosomal dominant, hereditary multiorgan disease with higher risk for malignancies (breast, thyroid, endometrium). Mucocutaneous lesions occur in 90% of cases and are characterized by facial trichilemmomas,  oral mucosal papillomas and benign acral keratoses. A case of 39-year-old female patient with a chief complaint of " white spots " on the upper and lower attached gingiva accompanyed with skin changes on the face, hands and soles is presented. Her family medical history revealed that her mother had endometrial polyp and sister thyroid cancer. In her medical personal history, she reported follicular thyroid adenoma, thyroid abnormalities (i.e. lymphocytic thyroiditis), fibrocystic change and juvenile breast papillomatosis, lipoma, multiple fibromas and genitourinary tumors. Based on the extensive family and personal medical history, physical examination and histopathological findings, diagnostic criteria were fulfilled for the diagnosis of Cowden syndrome.
Source: Acta Dermatovenerologica Croatica - Category: Dermatology Source Type: research