Versatile and Valuable Utilization of Amidohydrolase L-Glutaminase in Pharma and Food industries: A Review.

Versatile and Valuable Utilization of Amidohydrolase L-Glutaminase in Pharma and Food industries: A Review. Curr Drug Metab. 2020 Jan 15;: Authors: Durthi CP, Pola M, Rajulapati SB, Kola AK, Kamal MA Abstract L-Glutaminase has versatile applications in Pharma and food industries. In pharmaceutical industry, L-Glutaminase can used as anti-oxidant and anti-cancer agent to treat Acute Lymphocytic Leukaemia (ALL). Whereas, in food industry L-Glutaminase is used for acrylamide degradation, theanine production, flavour enhancer, soy sauce and many. The other applications include nitrogen metabolism and its use as biosensor in hybridoma technology. Both intra-cellular and extra-cellular L-Glutaminases from wide range of sources was identified. Because of its diverse applications, there is a need to improve the production of L-Glutaminase by enzyme engineering technology. Effect of recombination of L-Glutaminase production was also reported. Researchers also confirmed the antitumor properties of L-Glutaminase by conducting in vitro, in vivo and in silico studies. Bacillus sps. and Aspergillus sps. are the commercial producers of L-Glutaminase. In this review, the applications, different sources of L-Glutaminase, anti-cancer properties were discussed. PMID: 31951174 [PubMed - as supplied by publisher]
Source: Current Drug Metabolism - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Metab Source Type: research