Effect of the micro-environment on α-synuclein conversion and implication in seeded conversion assays

ConclusionThe variable diagnostic accuracy of current α-synuclein RT-QuIC occurs due to different protocols, cohorts and material etc.. An impact of micro-environmental factors on the α-synuclein aggregation and conversion process and the occurrence and detection of differential misfolded α-synuclein types or strains might underpin the clinical hete rogeneity of α-synucleinopathies.
Source: Translational Neurodegeneration - Category: Neurology Source Type: research