Improvement of efficacy and decrement cytotoxicity of oxaliplatin anticancer drug using bovine serum albumin nanoparticles: synthesis, characterisation and release behaviour
To sustained release of an anticancer drug, oxaliplatin (OX), a non-toxic and biocompatible nanocarrier based on bovine serum albumin (BSA) were synthesised by desolvation method and characterised using Fourier-transform infrared (FTIR) spectroscopy, field emission scanning electron microscopy (FESEM), atomic force microscopy (AFM) and dynamic light scattering. The results showed that the BSA nanoparticles (BSANPs) with a mean magnitude of 187.9 ± 1.2 nm have spherical morphology with a smooth surface and a uniform distribution. Furthermore, OX was loaded onto the BSANPs and the loading was confirmed by FTIR, AFM and FESEM techniques. The percentage of encapsulation efficiency and drug loading were determined by absorption spectroscopy (UV–vis). The drug release studies showed that release of OX from BSANPs exhibited slower release rate. However, the release kinetics followed the first-order kinetic for both of them with the non-Fickian release behaviour. The electrochemical analysis showed stability of OX loaded onto the BSANPs (OX@BSANPs) and confirmed the diffusion mechanism. Furthermore, the results of MTT assay revealed increasing of normal cell viability and cancer cell death in the OX@BSANPs compared to only OX. It was shown that the BSANPs could be safely used as a biocompatible nanocarrier for the sustained release of OX.
Steve Lindsay, a public health entomologist at Durham University, is midway through explaining how dogs might play a role in detecting COVID-19 infections when a decidedly less-well trained canine interrupts our conversation. “If you’ll excuse me for a minute, I’ve got a naughty black Labrador out in the back garden doing something it shouldn’t be doing,” Lindsay says. He disappears. I hear barking. He returns accompanied by a chocolate lab. “She’s not as skilled as the detection dogs,” Lindsay says as the pup tries to lick his face. “But it’s really interesting t...
Women with high-risk breast tumors had more than double the chance of distant...Read more on AuntMinnie.comRelated Reading: 2 breast lesion traits that signal future cancer risk CT scans can predict CVD risk in breast cancer patients Image-guided biopsy spots residual breast cancer Radiologists, AI make a great team in screening mammo Interval breast cancers have unique characteristics
Rationale: Prostate-specific membrane antigen positron emission tomography-computed tomography (18F-PSMA-1007 PET/CT) imaging is an emerging method for the diagnosis of prostate cancer (PC), but its efficiency in detecting other accompanying diseases has rarely been investigated. Patient concerns: A 77-year-old man presented with a complaint of bone pain throughout his entire body lasting for 2 weeks. Routine preoperative whole-body bone scanning revealed multiple osteogenic metastases. His alpha-fetoprotein and prostate-specific antigen levels were 108.2 ng/mL and 53.32 ng/mL, respectively. 18F-PSMA-1007 PET/...
In this study, we show that18F-DCFPyl might detect neovasculature in advanced, metastatic differentiated thyroid cancer (DTC). We first stained the preserved lymph node samples of three patients with DTC who had undergone total thyroidectomy and neck dissection for cervical lymph node metastatic disease to identify PSMA expression, with the PSMA antibody (DAKO Monoclonal). Then, we performed18F-DCFPyl imaging in two other advanced DTC patients with elevated serum thyroglobulin (Tg), indicative of residual disease. We compared the findings with contemporaneous FDG PET/CT scan, conventional Imaging (CT,MRI) and whole-body sc...
This article provides a structured literature review of the most important studies investigating the role of PET or PET/CT in the clinical practice of MCC.
Conclusion: The formulated novel QDs-OCD can target SSTR2 overexpressed in blood cells with great potential for treating blood cancer.
ConclusionsThis study demonstrated the feasibility of total laparoscopic pancreaticoduodenectomy combined with vascular resection and artificial vascular graft reconstruction in properly selected cases of pancreatic cancer with vein involvement after neoadjuvant chemotherapy. It is worth noting that skilled laparoscopic technicians and effective teamwork are necessities for safe completion of the procedure.
ConclusionPET/MR provides a more precise assessment of the local extent of rectal cancers in evaluating cancer length, N status, and external sphincter involvement. PET/MR offers the opportunity to improve clinical decision-making, especially when evaluating low rectal tumors with possible external sphincter involvement.
Image-guided biopsies performed after breast cancer patients have been treated...Read more on AuntMinnie.comRelated Reading: CT scans can predict CVD risk in breast cancer patients Breast screening helps precision medicine succeed Radiation tied to breast cancer delays for Black women Women with DCIS have 3x the risk of breast cancer death Delayed breast cancer surgery not tied to worse outcomes
We report a case of a patients affected by breast cancer who underwent PET/CT after therapy; a focal 18F-FDG uptake of not univocal interpretation was observed between liver and pleura. A subsequent acquisition on the right lateral decubitus showed the pleural location of lesion, thus improving the diagnostic accuracy of the PET/CT finding. PMID: 33020233 [PubMed - as supplied by publisher]