Similar impairments shown on a neuropsychological test battery in adolescents with high-functioning autism and early onset schizophrenia: a two-year follow-up study.

Conclusion: The findings suggest that it may be difficult to differentiate adolescents with EOS and ASD based on neuropsychological task performance. An implication of the results is that adolescents with either disorder may benefit from a similar approach to the treatment of cognitive impairment in the disorders. PMID: 31931670 [PubMed - as supplied by publisher]
Source: Cognitive Neuropsychiatry - Category: Psychiatry Tags: Cogn Neuropsychiatry Source Type: research

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Conditions:   Schizophrenia;   Learning Disorders;   Executive Function Disorders Interventions:   Diagnostic Test: Standardised semi-structured talk;   Diagnostic Test: Autistic spectre disorder screening;   Diagnostic Test: Anxiety measuring Sponsor:   Assistance Publique - Hôpitaux de Paris Recruiting
Source: - Category: Research Source Type: clinical trials
Conclusions: The approach of reprograming case-parent tr ios represents a possibility of investigating disease-causing mutations and comparing cell lines with reduced variation in genetic background. Our results are indicative of an overlap between schizophrenia and autism-related phenotypes in the investigated family.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Social affiliative behaviors -- engagement in positive (i.e. non-aggressive) social approach and reciprocal social interactions with a conspecific -- comprise a construct within the NIMH RDoC Social Processes Domain. Affiliative behaviors are disrupted in multiple human neurodevelopmental and neuropsychiatric disorders, such as autism, schizophrenia, social phobia, and others. Human genetic studies have strongly implicated synaptic cell adhesion molecules (sCAMs) in several such disorders that involve marked reductions, or other dysregulations, of social affiliative behaviors.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Review Source Type: research
UCLA researchers have found that it is possible to assess a person ’s ability to feel empathy by studying their brain activity while they are resting rather than while they are engaged in specific tasks.  Traditionally, empathy is assessed through the use of questionnaires and psychological assessments. The findings of this study offer an alternative to people who may have difficulty filling out questionnaires, such as people with severe mental illness or autism, said senior author Dr. Marco Iacoboni, professor of psychiatry and biobehavioral sciences at the David Geffen School of Medicine at UCLA.“Assessi...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
Infection by the parasite Toxoplasma, which affects about 33% of world population, is associated with an increased risk of several mental health disorders, the most strongly with schizophrenia. It is unknown whether schizophrenia is associated with this infection the most strongly, or whether this association has just been the most intensively studied for historical reasons. We used the data from 6,367 subjects tested for toxoplasmosis who took part in an internet survey to search for associations of these infections with 24 mental health disorders and evidence of otherwise impaired mental health. The typical symptom assoc...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
(Penn State) Neurodevelopmental disorders, including schizophrenia and autism, likely result from complex interactions that modify the effects of individual genes, according to new research.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
by Mayanglambam Dhruba Singh, Matthew Jensen, Micaela Lasser, Emily Huber, Tanzeen Yusuff, Lucilla Pizzo, Brian Lifschutz, Inshya Desai, Alexis Kubina, Sneha Yennawar, Sydney Kim, Janani Iyer, Diego E. Rincon-Limas, Laura Anne Lowery, Santhosh Girirajan The 1.6 Mbp deletion on chromosome 3q29 is associated with a range of neurodevelopmental disorders, including schizophrenia, autism, microcephaly, and intellectual disability. Despite its importance towards neurodevelopment, the role of individual genes, genetic interactions, and disrupted biologi cal mechanisms underlying the deletion have not been thoroughly characterize...
Source: PLoS Genetics - Category: Genetics & Stem Cells Authors: Source Type: research
ré C Abstract We tested endogenous pain modulation mechanisms in adults with autism spectrum disorders (ASD). Nineteen ASD adults without intellectual disabilities were included, matched with 19 healthy volunteers on the basis of sex and chronological age. An experimental pain model was used to measure excitatory and inhibitory pain mechanisms in a single session. Statistical analyses indicated that endogenous pain modulation mechanisms in ASD group did not differ significantly from those of healthy adults. The pain scores were very disparate in ASD group with a greater range of extreme scores than in contr...
Source: Journal of Autism and Developmental Disorders - Category: Psychiatry Authors: Tags: J Autism Dev Disord Source Type: research
This study investigated whether antenatal exposure to antidepressants (ADs) increases the risks of autism spectrum disorders (ASD), attention deficit/hyperactivity disorders (ADHD), schizophrenia and other mental illnesses, and cognitive and developmental deficits in infants or preschool children. PubMed, EMBASE, BIREME/BVS databases were searched to identify studies examining associations of ADs in pregnancy with neurodevelopmental and psychiatric disorders. Twenty studies addressed ASD and/or ADHD risks while 30 focused on developmental and cognitive deficits in infants or preschool children. Most studies detected no ass...
Source: Cadernos de Saude Publica - Category: International Medicine & Public Health Authors: Tags: Cad Saude Publica Source Type: research
Conclusions. The present review of the orbitofrontal sulcogyral pattern indicated that type I expression might reflect a neurodevelopmental protective marker, and type II and III expressions, as well as fewer numbers of IOS and POS, might reflect neurodevelopmental risk markers. These trait markers may be transdiagnostic among socially disabling diseases. PMID: 32028799 [PubMed - as supplied by publisher]
Source: Clinical EEG and Neuroscience - Category: Neuroscience Authors: Tags: Clin EEG Neurosci Source Type: research
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