Mechanisms of acquired in vivo and in vitro resistance to voriconazole by Candida krusei following exposure to suboptimal drug concentration.

Mechanisms of acquired in vivo and in vitro resistance to voriconazole by Candida krusei following exposure to suboptimal drug concentration. Antimicrob Agents Chemother. 2020 Jan 13;: Authors: Ricardo E, Grenouillet F, Miranda IM, Silva RM, Eglin G, Devillard N, Rodrigues AG, Pina-Vaz C Abstract Five C. krusei isolates (susceptible and resistant) recovered from the urine of a kidney transplant patient treated with VRC 200mg/2x day for 20 days were studied. Eight unrelated clinical isolates of C. krusei were exposed in vitro to VRC 0.001 μg/ml, during 30 days. Development of VRC transient resistance occurred in vivo and induction of permanent resistance occurred in vitro Mostly ABC1 and ERG11 genes were overexpressed and a homozygous T418C mutation in ERG11 gene was found. PMID: 31932372 [PubMed - as supplied by publisher]
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research