Meta-Analysis of Randomized Controlled Trials Using Botulinum Toxin A at Different Dosages for Urinary Incontinence in Patients With Overactive Bladder

Conclusions: This meta-analysis indicated that BTX-A 200U and 300U are more effective than placebo in the treatment of NDO, with minimal, local, and manageable adverse events. Furthermore, BTX-A 300U and 200U could also improve detrusor compliance of IOAB. However, more RCTs would still be necessary to explore the effect of BTX-A on management of UI in NDO and IOAB patients.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research

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In this study, the genomes of 66 E. coli isolates from adult female bladders were sequenced. These isolates were collected from four cohorts, including women: (1) without lower urinary tract symptoms, (2) overactive bladder symptoms, (3) urgency urinary incontinence, and (4) a clinical diagnosis of UTI. Comparative genomic analyses were conducted, including core and accessory genome analyses, virulence and motility gene analyses, and antibiotic resistance prediction and testing. We found that the genomic content of these 66 E. coli isolates does not correspond with the participant’s symptom status. We thus looked bey...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
ConclusionImidafenacin demonstrated efficacy and safety in the treatment of OAB in Taiwanese patients.
Source: LUTS: Lower Urinary Tract Symptoms - Category: Urology & Nephrology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Most people know that microorganisms live on our skin, and in other places in the body such as the digestive tract. However, traditional thinking and medical teaching was that there was no such microbiome in the urinary tract. Many people may still believe that urine is sterile. Advanced detection methods such as enhanced urine cultures and DNA sequencing have shown that this is not true. These newer technologies have enabled identification of low levels of microorganisms that were not previously detected using conventional methods. This has revolutionized how we think about the urinary tract when it is both healthy and un...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Incontinence Kidney and urinary tract Women's Health Source Type: blogs
AbstractBackgroundIn older patients with overactive bladder (OAB), mirabegron, a β3-adrenoreceptor agonist, represents an alternative treatment that may have a favorable risk –benefit profile.ObjectivesOur objective was to further examine the safety and tolerability of mirabegron versus placebo treatment in patients aged  ≥ 65 years with OAB-wet.MethodsWe conducted a 12-week, double-blind, randomized, placebo-controlled phase IV study to compare mirabegron with placebo. Community-dwelling patients aged  ≥ 65 years with OAB-wet (one or more incontinence episode and thre...
Source: Drugs and Aging - Category: Geriatrics Source Type: research
Conclusion: Producing recommendations for managing LUTS in children based on high-quality studies is not possible. LUTS in children should be evaluated in a multimodal way by minimal invasive diagnostic procedures. Urotherapy is the mainstay of treatment and specific medical treatment is added in refractory cases.What is Known:• Symptoms of the lower urinary tract may have significant social consequences and sometimes clinical morbidities like urinary tract infections and vesicoureteral reflux. In many children, however, there is no such obvious cause for the incontinence, and they are referred to as having functional...
Source: European Journal of Pediatrics - Category: Pediatrics Source Type: research
Overactive bladder (OAB) is a bladder storage symptom-syndrome defined as “urinary urgency, usually accompanied by frequency and nocturia, with or without urge urinary incontinence (UUI), in the absence of urinary tract infection or other obvious pathology” [1]. OAB adversely affects daily activities, sleep, mental health, sexual function and general well-being of pat ients [2]. In fact, the negative impact on quality of life increases with the number of OAB symptoms and the psychological stress level [2,3].
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - Category: OBGYN Authors: Tags: Review article Source Type: research
A 69-year-old Asian man with a history of overactive bladder presented with postvoid dribbling and urinary incontinence in the past three years. He had cervical spinal stenosis surgery one month ago and two episodes of urinary tract infections with multidrug-resistant Escherichia coli species in urine culture in the last three months. Digital rectal examination revealed a 1-cm hard nontender nodule within the right side of his prostate, concerning for possible prostatic malignancy. Ultrasound study identified a hypoechoic area in the right lateral prostate. Serum prostate-specific antigen level was 2.03 ng/mL (reference ra...
Source: Pathology Case Reviews - Category: Pathology Tags: Case Reviews Source Type: research
ConclusionsRates of UTI were similar in patients undergoing BTX and SNM. MDR UTI was rare. Patients with prior prolapse repair or recurrent UTI may be at a higher risk of UTI after either procedure.
Source: International Urogynecology Journal - Category: OBGYN Source Type: research
Overactive bladder syndrome (OAB) is defined by the International Continence Society (ICS) as a clinical syndrome characterized by urinary urgency, usually accompanied by frequency and nocturia, with or without urgency urinary incontinence, in the absence of urinary tract infection or other obvious pathology [1]. Its prevalence is higher in women than in men and increases with advancing age [2]. In Brazil, Moreira et al., in 2013, found a prevalence of OAB of 5.1% in males and 10% in females among adults, and in the elderly, a prevalence of 78% in males and 82% in females.
Source: Maturitas - Category: Primary Care Authors: Source Type: research
Overactive bladder (OAB) is a symptom complex that includes urinary urgency, frequency, urgency incontinence, and nocturia. It is highly prevalent, affecting up to 12% of the adult population, and can significantly impact quality of life. The diagnosis of OAB is made by history, physical examination, and a urinalysis to rule out underlying infection or other concerning potential etiologies. The need for additional testing is based on the initial evaluation findings, and is recommended in cases of underlying urinary tract infection, microscopic hematuria, obstructive voiding symptoms, and symptoms refractory to previous treatments.
Source: Mayo Clinic Proceedings - Category: Internal Medicine Authors: Tags: Concise review Source Type: research
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