[Seminar] Gastrointestinal stromal tumour

Gastrointestinal stromal tumours (GISTs) are mesenchymal neoplasms that arise in the gastrointestinal tract, usually in the stomach or the small intestine and rarely elsewhere in the abdomen. They can occur at any age, the median age being 60–65 years, and typically cause bleeding, anaemia, and pain. GISTs have variable malignant potential, ranging from small lesions with a benign behaviour to fatal sarcomas. Most tumours stain positively for the mast/stem cell growth factor receptor KIT and anoctamin 1 and harbour a kinase-activating mutation in either KIT or PDGFRA.

Source: LANCET - September 14, 2013 Category: Journals (General) Authors: Heikki Joensuu, Peter Hohenberger, Christopher L Corless Tags: Seminar Source Type: research