A Neutralization scFv Antibody against IL-1β Isolated from a NIPA-based Bacterial Display Library.
Conclusions: In this study, it is the first time to use the NIPA-based bacteria display system to construct and screen the combinatorial scFv library. Three scFvs against hIL-1β were obtained from the scFv library of the immunized mice. </p><p> Prokaryotically expressed and purified scFvs demonstrate binding ability with hIL-1β. Among the three clones, The MTT test suggests that scFv-20 is a neutralization antibody against hIL-1β. The study provides a lead candidate for further development of small molecule therapeutic antibodies for treatment of RA. </p><p>
PMID: 24016270 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Biotechnology - Category: Biotechnology Authors: Li T, Xu L, Ren G, Yin C, Zhou B, Ye X, Li Q, Li N, Li D Tags: Curr Pharm Biotechnol Source Type: research
More News: Autoimmune Disease | Biotechnology | Clinical Trials | Databases & Libraries | Genetics | Study