Antioxidant and antimicrobial poly-ε-caprolactone nanoparticles loaded with Cymbopogon martinii essential oil

Publication date: Available online 11 January 2020Source: Biocatalysis and Agricultural BiotechnologyAuthor(s): Bruna Jummes, William Gustavo Sganzerla, Cleonice Gonçalves da Rosa, Carolina Montanheiro Noronha, Michael Ramos Nunes, Fabiano Cleber Bertoldi, Pedro Luiz Manique BarretoAbstractPalmarosa (Cymbopogon martinii) essential oil is a rich source of geraniol monoterpene, with antimicrobial and antioxidant properties. However, bioactive compounds present chemical instability under adverse temperature conditions due to their high volatility characteristics. Therefore, the aim of this work was to produce poly-ε-caprolactone nanoparticles entrapped with palmarosa essential oil and geraniol, the majoritarian compound of palmarosa essential oil. Entrapped nanoparticles were characterized by particle size, polydispersity index, zeta potential, morphology, encapsulation efficiency, differential scanning calorimetry (DSC), antioxidant capacity and antimicrobial activity. The average sizes of the loaded nanoparticles was 282.1 ± 0.4 nm and 289.3 ± 1.5 nm, for geraniol and palmarosa oil respectively, and 207.8 ± 0.1 nm for the free loaded nanoparticles. The polydispersity results were lower than 0.140, indicating a unimodal distribution. All formulations showed zeta potential lower than 30 mV, indicating a good stability. High values of encapsulation efficiency were obtained, explained by the hydrophobicity of the essential oil and geraniol. Evaluating the ...
Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research