Proliferation inhibition and apoptosis induction of imatinib-resistant chronic myeloid leukemia cells via PPP2R5C down-regulation

In conclusion, the suppression of PPP2R5C by RNA interference could inhibit proliferation and effectively induce apoptosis in CML cells that were either imatinib sensitive or resistant. Down-regulating PPP2R5C gene expression might be considered as a new therapeutic target strategy for CML, particularly for imatinib-resistant CML.

Source: Journal of Hematology and Oncology - September 3, 2013 Category: Hematology Authors: Qi ShenSichu LiuYu ChenLijian YangShaohua ChenXiuli WuBo LiYuhong LuKanger ZhuYangqiu Li Source Type: research