Current and future approaches to screening for endometrial cancer

Publication date: Available online 2 January 2020Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): A. Gentry-Maharaj, C. KarpinskyjAbstractDue largely to the rise in obesity and prolonged life expectancy, endometrial cancer rates have increased by 56% since the early 90s. Women at high risk (Lynch Syndrome) have a 12-47% lifetime risk of developing endometrial cancer and professional societies recommend annual surveillance using transvaginal ultrasound (TVS) and endometrial biopsy (outpatients hysteroscopy) from age 30-35 with hysterectomy from age 40. In women at low risk, screening is not currently advocated. The emerging data from Genome Wide Association studies in combination with epidemiological data may refine risk stratification in the future. In addition to screening, preventative approaches such as intrauterine progesterone may help reduce disease burden in those identified at ‘higher risk’.
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - Category: OBGYN Source Type: research