Circulating NEDD9 is Increased in Pulmonary Arterial Hypertension: A Multicenter, Retrospective Analysis

Pulmonary arterial hypertension (PAH) is a highly morbid disease characterized by elevated pulmonary vascular resistance (PVR) and pathogenic right ventricular (RV) remodeling. Endothelial expression of the pro-metastatic protein NEDD9 is increased in fibrotic PAH arterioles, and NEDD9 inhibition decreases PVR in experimental PAH. We hypothesized that circulating NEDD9 is increased in PAH and informs the clinical profile of patients.

Source: The Journal of Heart and Lung Transplantation - December 30, 2019 Category: Transplant Surgery Authors: Andriy O. Samokhin, Steven Hsu, Paul B. Yu, Aaron B. Waxman, George A. Alba, Bradley M. Wertheim, C. Danielle Hopkins, Frederick Bowman, Richard N. Channick, Ivana Nikolic, Mariana Faria-Urbina, Paul M. Hassoun, Jane A. Leopold, Ryan J. Tedford, Corey E. Source Type: research