Contribution of cortical and white matter lesions to cognitive impairment in multiple sclerosis

Conclusions:
These findings suggest a role of WM lesions in the development of cognitive deficits, especially information-processing speed, which may be higher than previously assumed.

Abbreviations:
CES-D: Center for Epidemiologic Studies Depression scale (ADS-L: Allgemeine Depressions Skala-L, German version of CES-D), CIS: clinically isolated syndrome, CL: cortical lesion, DIR: double inversion recovery, EDSS: Expanded Disability Status Scale, FSMC: fatigue scale for motor and cognitive functions, GM: grey matter, MRI: magnetic resonance imaging, MS: multiple sclerosis, PASAT-3: paced auditory serial addition test 3s, PPMS: primary progressive multiple sclerosis, RRMS: relapsing–remitting multiple sclerosis, SDMT: symbol digit modalities test, SPM: statistical parametric mapping, SPMS: secondary progressive multiple sclerosis, WM: white matter

Source: Multiple Sclerosis - August 30, 2013 Category: Neurology Authors: Papadopoulou, A., Muller-Lenke, N., Naegelin, Y., Kalt, G., Bendfeldt, K., Kuster, P., Stoecklin, M., Gass, A., Sprenger, T., Radue, E. W., Kappos, L., Penner, I.-K. Tags: Research Papers Source Type: research