Distinct chronic post-viral lung diseases upon infection with influenza or parainfluenza viruses differentially impact superinfection outcome.
In this study, we cross-analyzed chronic lung disease caused by infection with Sendai virus (SeV) or influenza A virus in mice. Differences wee observed in both lesion composition and inflammatory profiles between SeV- and influenza A virus-induced long-term lung disease. In addition, a primary SeV infection led to worsened pathology upon secondary heterologous viral challenge while the reversed infection scheme protected from disease in response to a secondary viral challenge more than a month after the primary infection. These data demonstrate the differential impact of primary viral infections in the susceptibility to disease exacerbation in response to a different secondary viral infection and highlight the usefulness of these viral models as tools to understand the underlying mechanisms mediating distinct chronic post-viral lung diseases.
PMID: 31866346 [PubMed - as supplied by publisher]
Source: The American Journal of Pathology - Category: Pathology Authors: Garcia GL, Valenzuela A, Manzoni T, Vaughan A, López CB Tags: Am J Pathol Source Type: research
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